ABSTRACTDifferent syrup samples of expired dates were collected from local available outlets of North Gujarat region.  Around 30 samples of drugs were selected for microbial analysis. Sample includes cough syrup, ear drops, eye drops and antibiotic in liquid form etc. while drugs included paracetamol, ofloxacine, paradichlorobenze, cefpodoxime and Levocelirizine in liquid form. Each sample was inoculated in Nutrient broth at 37°C for 24-48 hours. Same samples were also inoculated for fungal growth in Sabouraud dextrose broth  at 28°C for 3-4 days. Samples and all different colonies were studied using morphological and biochemical characteristics. Result concluded presence of   Bacterial sp. including Staphlococcus aureus, S.epidermis,Pseudomonas sp,Bacillus sp., Enterococcus sp.,Microbacterium sp etc. whereas Fungal sp. include  Aspergillus niger,Mucor sp.,Aspergillus sp., Neurospora sp. etc. Keywords: Expired drugs, Bacterial and fungal species, Morphological and biochemical characteristics.