ABSTRACTAqua gel is a polymeric gel formulated by using crosslinking agent to form a network of crosslinked polymer chains. It is a hydrophilic structure with capability of holding water in their three-dimensional networks. Formulation and comparative evaluation of Diclofenac aqua gel by using various polymers have been carried out to check efficient concentration of various polymers as well as to choose an appropriate polymer. Diclofenac has chosen as an active pharmaceutical ingredient which have tendency to cause acidity or GI irritation when comes in contact with GI fluid. Avoidance of such side effect is one of the motives of this research. Administration of Diclofenac trans dermally will avoid to get contact with GI fluid as well as avoid GI irritation. In this research various concentration of polymer has been taken to compare between polymer concentration as well as various polymer efficiency.Keywords: Aqua gel, Hydrogel, topical gel, Diclofenac gel, hydrophilic gel.