ABSTRACTSphagneticola trilobata (L.) Pruski, also known as Wedelia trilobata (L.), is a tropical perennial flowering plant which is distributed across various parts of the world. This plants has been used as a traditional folk medicine in India, China and other parts of the world. The plant possesses a large number of phytochemicals that contributes to its different pharmacological activities. The various pharmacological activities reported in S. trilobata include antioxidant activity, analgesic activity, anti-tumor activity, anti-bacterial activity, anti-fungal activity, anti-inflammatory activity, cental nervous system depressant activity, anti-diabetic activity and in the treatment of menstrual pain (dysmenorrhea). This plant also possess larvicidal activity, anti-hypertensive activity, apoptotic activity, anti-proliferative activity, cytotoxic effects and anti-pyretic activity. Further studies in this plant and its phytoconstituents will reveal more pharmacological activities. It will provide a way for developing lead molecules which may further be used for the development of novel medicinal agents. Keywords: Sphagneticola trilobata, pharmacological activity, phytoconstituents.