ABSTRACTThe menopausal state is itself noted to be an independent risk factor  for the occurrence of metabolic syndrome. This study was conducted to find the prevalence of metabolic syndrome in postmenopausal women. It was an Observational study. Total 100 females were enrolled, 50 premenopausal(Group I) and 50 menopausal (Group II) were included in the study. There was a statistic significant increase in serum glucose, serum total cholesterol (TC), triglycerides (TG), LDL-cholesterol, VLDL-cholesterol levels, insulin, insulin resistance in post-menopausal women. HDL-cholesterol level and estradiol concentration was significantly lower in post-menopausal women. Menopause leads to changes in blood glucose, serum insulin, lipid profile by reducing HDL, and elevating total cholesterol (TC), triglycerides (TG), LDL-cholesterol and VLDL-cholesterol, thus increasing the risk for cardiovascular disease. These changes are caused by reduced estrogen concentrations which are seen in menopause. Keywords: Menopause, metabolic syndrome, postmenopausal women, cardio vascular disease.