ABSTRACTBenzimidazole derivatives are versatile nitrogen containing heterocyclic compound which have long been known as a promising class of biologically active compounds possessing wide variety of a biologically active compound like antiprotozoal, anticoagulant, antifungal, antihistaminic, antiulcer activities. Benzimidazole is outstanding effective compounds and these are a number of reviews available for biochemical and pharmacological studies. This review article covers the most active benzimidazole derivative and discusses the structure and their uses. Keyword: Benzimidazole, Heterocyclic compound, Benzimidazole derivative, Antifungal, Antiprotozoal activity, Antihistaminic