ABSTRACTIn this review, the most important Pd-catalyzed C-C cross-coupling named reactions have been presented and discussed. It has been proposed that in Pd-catalysed reactions, the Pd decreases the activation energy or reacting species by simply stabilizing the transition state as it is an unstable and short-lived. The catalyst may get coordinated to one or more of the reactants and remains coordinated throughout the transition state of the catalytic process. During this process, the dissociation of the product either regenerates the Pd directly or generates a species that will be converted into the Pd. This is a typical in enzyme–catalyzed processes occurs in organometallic chemistry.  Keywords: Cross-coupling, Catalytic, enzyme, organometallic, short-lived.