ABSTRACTThe main aim of the study was to design Perphenazine solid lipid nanoparticles and to evaluate them. The Perphenazine solid lipid nanoparticles were prepared by the hot homogenization followed by ultrasonication method by using the different lipids (Tristearin, GMS, Compritol) Soya lecithin as stabilizer and Tween-80 used as surfactant. The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and lipids. Then nanoparticles were evaluated for particle size, PDI, zeta potential, entrapment efficiency and in-vitro drug release. The particle size ranged from 53.46 to 518.6 d.nm, PDI ranged from 0.284 to 0.502, zeta potential from -9.83 to -40.96 mV and entrapment efficiency was ranged from 77.45 to 95.38%.The cumulative percentage release from all SLNs varied from 53.35 to 88.74 % after 24hours depending upon the drug and lipid ratio and F2 formulation showed highest drug release i.e., 88.74%. The release kinetic studies showed that the release first order diffusion controlled and the n value (0.47) from the Korsmeyer-Peppa’s model indicated the release mechanism was Quasi-fickian type. Keywords: Perphenazine, Solid lipid nanoparticles, FTIR, in-vitro drug release.