ABSTRACTIn Unani system of medicine Sharbat Bazoori Motadil and Majoon Dabedulward are compound formulation is effective in the treatment of Amraz-e- Jigar and may be useful in the treatment of Cholecystitis also. So, the aim of this study is to evaluate the efficacy of Unani Formulation on scientific parameters. This study was an open observational study, carried out on 40 patients. The test drug was given in the form of decoction with 7 gm Majoon Dabidul Ward with 50 ml Sharbat Bazoori Moatadil twice a day after meal for the period of 2 months. All the patients of were assessed fortnightly on subjective parameters (0th, 15th, 30th 45th and 60th day) whereas objective parameters were assessed before and after the treatment. The outcome of intervention was analyzed using appropriate statistical methods. Subjective parameters were satisfactorily alleviated by the test drugs. Findings suggest the effectiveness of test drug in Cholecystitis. Subjective parameters and the findings in USG and CT scan ere also improved. Keywords: Majoon Dabidul Ward; Sharbat Bazoori Moatadil; Cholecystitis; Warm-e-Marara.