ABSTRACTRheumatoid arthritis (RA) is an evolving, enduring, and a crippling disorder categorized by puffiness, agony, and synovial joints arduousness. The exact reason of this devastating illness is mysterious. However, it is strongly linked to self-protection reaction triggered by various genetic and external factors. The current research work was designed to explore the anti-arthritic probable of the plant Erythroxylum monogynum. The plant leaves was collected, shade dried, blended and extracted (continuous hot percolation) with Hydro-alcoholic solvent. Preliminary phytochemical evaluation were carried out. Entirely the in-vitro models i.e. inhibition of protein denaturation, membrane stabilization and proteinase inhibition were carried out by using standard reference drug diclofenac sodium. In the present study there was significant (p