Effects of Ethanol extract of Ricinus Communis seed on some Hormonal profile in Bromocriptine induced Hypoprolactinemia in Female Albino rats.

This present study was undertaken to investigate the effects of ricinus communis ethanol extract on serum prolactin, LH and FSH levels in bromocriptine-induced hypoprolactinemia in female albino rats. A total of thirty female albino rats divided into 5 groups (Groups I, II, III, IV and V) consisting of 6 rats in each group were used for the study. Group I served as Control, while II, III, IV and V served as experimental groups. The experimental groups received 10mg/kg of bromocriptine orally at interval of 6 hours daily for 4 weeks. Groups III, IV and V were given respectively 200mg/kg/day, 500mg/kg/day and 900mg/kg/day of ricinus communis orally for 4 weeks. Group I received distilled water and normal rat chow. Results showed statistically significant decrease in prolactin level (P < 0.05) in rats treated with ricinus communis extract. There was statistically significant increase in serum LH and FSH levels (P < 0.05) in rats treated with ricinus communis extract. The present study suggested that ricinus communis extract in a dose related pattern significantly lowered serum prolactin level but caused a significant increase serum LH and FSH levels respectively in bromocriptine induced hypoprolactinemia in female rats.