American Journal of Pharmacy and Health Research

The goal of the current study is to formulate and evaluate a herbal syrup that contains Gokhuru (Tribulus terrestris Linn.), a medicinal plant that is frequently used in traditional Ayurvedic medicine to treat renal and urinary issues. Because gokhuru contains bioactive components such steroidal saponins, flavonoids, alkaloids, glycosides, and tannins, it has important pharmacological properties like diuretic, anti-urolithiatic, nephroprotective, antiinflammatory, and aphrodisiac actions. Gokhuru's dried fruits were gathered, verified, prepared, and extracted using an aqueous extraction technique. To formulate a tasty and stable herbal formulation, the extract was added to a syrup basis that had been made with the appropriate sweetening, flavoring, and preservative ingredients. Color, odor, taste, pH, viscosity, specific gravity, refractive index, and total soluble solids were among the organoleptic and physicochemical characteristics of the prepared syrup that were assessed. To guarantee the formulation's stability and safety, stability tests and microbial quality evaluation were also carried out. The prepared syrup had good stability during storage, satisfactory microbiological quality, and acceptable physicochemical properties, according to the results. The Gokhuru herbal syrup is a stable, safe, and patient-friendly dosage form with potential therapeutic benefits for renal and urinary tract problems, according to the study's findings. The formulation and standardization of herbal liquid formulations for better patient compliance and broader use in contemporary healthcare systems is supported by this work.

Objective: The aim of this study was to evaluate the pharmacological effects of an aqueous extract of leaves, flowers and pods of Crotalaria retusa (Fabaceae) on the blood glucose levels of streptozotocin-induced diabetic rats. Results: The phytochemical test revealed the presence of polyphenols, flavonoids, catechin and gallic tannins, quinonic compounds, alkaloids, sterols and polyterpenes. However, saponins were not detected in the aqueous extract of Crotalaria retusa. Administration of the aqueous extract of Crotalaria retusa at doses of 1000 and 600 mg/kg body weight resulted in a significant decrease in blood glucose levels in diabetic rats from day 28 until the end of treatment (84 days). The aqueous extract of Crotalaria retusa appears to have antidiabetic properties. These results would justify the use of this plant in traditional medicine for the treatment of diabetes.

The common dermatological issue is skin dehydration caused by low moisture retention, damaging the skin barrier. Traditional methods of moisturizing formulations depend on human or animal studies, which raises ethical issues and expenses. The present study aims to develop and study a collagen-gelatin artificial skin model and the hydration efficacy of an herbal gel made with leaf extract from Portulaca oleracea (purslane) and root extract from Imperata cylindrica (cogon grass). Artificial skin membranes (F1 and F2) were made from collagen and gelatin respectively, with glycerine as a plasticizer and glutaraldehyde as a cross-linking agent. Among these, formulation F2 showed high structural integrity due to the increased concentration of gelatin and was taken as the optimized membrane. The optimized artificial skin demonstrated an average thickness of 1.08 mm, with pH of 6.8, indicating compatibility with physiological skin conditions. Dryness was successfully induced by treating the membrane with 1% sodium dodecyl sulfate for 30 minutes. Herbal gel formulations (G1, G2, and G3) were made with Carbopol as gelling agent and was tested for physicochemical conditions. Among three formulations, G3 had optimized performance, with high moisture uptake, reduced water loss, and prolonged moisture retention. Overall, the developed artificial skin model proved to be reliable, cost-effective, and ethically acceptable in vitro method for preliminary screening of topical moisturizing formulations.