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American Journal of Pharmacy and Health Research

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“THE SYNTHESIS A SERIES OF 2 – ANILINOPHENYLACETIC ACID DERIVATIVS FOR THEIR ANTIMICROBIAL ACTIVITY”

Published in August 2026 Issue 08 (Vol. 14, Issue 8, 2026)

“THE SYNTHESIS A SERIES OF 2 – ANILINOPHENYLACETIC ACID  DERIVATIVS FOR THEIR ANTIMICROBIAL ACTIVITY” - Issue cover

Abstract

The synthesis of a series of 2-anilinophenylacetic acids, close analogue of diclofenac, is synthesized and tested for their anti-microbial activity by disk diffusion method. Each 2-anilinophenylacetic acid derivative will be screened for their anti-microbial activity. Syntheses have been carried out following simple methodology in excellent isolated yields. It has been found that compounds AB11, AB12, AB14, AB21, AB24, AB25, AB32, AB34, AB35, AB44, AB45 and AB54 showed the good activity against both of strain comparable to ampicillin and ciprofloxacin was taken as standard at the same concentration whereas all the other compound has showed mild to moderate anti-microbial activity as compared to standard drug. The structure and purity of the original compounds were confirmed by Melting Point, IR, TLC and elemental analysis. Each 2-anilinophenylacetic acid derivative will be screened for their anti-microbial activity. These preliminary results indicate that some of compounds are exhibiting good activity. -------------------------------------------------------------------------------------------------------------------------------------

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Authors (4)

*Dr. Narendra Singh

Alwar Pharmacy College, Alwar,...

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Dr. Govindasamy Jeyabalan

Alwar Pharmacy College, Alwar,...

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Dr. Yogendra Singh

1,2,4Alwar Pharmacy College, A...

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Mr. Jitendra Kumar Sharama

Alwar Pharmacy College, Alwar,...

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AJPHR8140006

AJPHR-01-000947

119-153

2026-08-07

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Narendra, *., & Govindasamy, D. & Yogendra, D. & Mr. Jitendra Kumar Sharama (2026). “THE SYNTHESIS A SERIES OF 2 – ANILINOPHENYLACETIC ACID DERIVATIVS FOR THEIR ANTIMICROBIAL ACTIVITY”. American Journal of Pharmacy and Health Research, 14(8), 119-153. https://ajphr.com/articles/AJPHR8140006

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