Comparative Analysis of Synthesis of A Few Novel 2-Pyrazoline Derivatives

A popular group of nitrogen containing heterocyclic compounds, pyrazoles and pyrazolines [dihydropyrazoles] have been extensively studied. These compounds are easy to synthesize and moreover different moieties can be introduced in the hetero system with suitable reaction conditions. The biological activity that has been investigated include antibacterial, antimicrobial, antimalarial, antifungal, antitumor and anticancer amongst several others. Among all the pyrazolines, 2-pyrazolinehave gained maximum attraction and is the most frequently studied one. Pyrazolines, synthesized from chalcones, have also been studied extensively for cytotoxicity. In the present work some novel 2-pyrazoline derivatives have been synthesized and characterized. For the synthesis conventional as well as non-conventional methods has been adopted and a comparative analysis has been studied.