Vancomycin Induced Red Man Syndrome in Infant with Obstructive hydrocephalus 2o to Arnold Chain Malformation

6 months old Indian Girl with underlying obstructive hydrocephalus secondary to Arnold-Chiari malformation and ruptured lumbosacral myelomeningocele, repaired on Day 2 of life (19/12/13) with problem of gross hydrocephalus block VP shunt associated with CONS, for removal of VP shunt and Omaya reservoir on Saturday with Day 26 post-revision of VP shunt. Child completed IV Cefazolin 280mg QID for 14days, CSF C&S x3 shows Staphyloccus Aureus coagulase negative, currently on IV Vancomycin 85mg 8hourly (15mg/kg/dose). Child developed facial puffiness and periorbital edema after last IV Vancomycin dose. No reaction after latest dose of IV Vancomycin.