Wound Healing Potential of Abrus Precatorius in Normal and Diabetic Rats

The ethanolic extract of Abrus precatorius leaves was screened for Wound Healing potential in normal and diabetic rats using excision and incision wound model. In excision wound model, normal and alloxan induced diabetic group of animals treated with AP 5% and 10% ointment showed significant increase in wound contraction and decrease in epithelization period as compared to control. In incision wound model, normal and alloxan induced diabetic group of animals treated with AP 5% and 10% ointment showed significant increase effect on breaking strength compared with control group. Histopathological findings of AP 5% and 10% ointment also showed, less inflammatory changes, increase tissue proliferation as well as remodelling along with re-epithelization, increase collagen fiber along with low scar formation as compared to control group. Findings of the results thus revealed that the ethanolic extract of Abrus precatorius (AP) has showed significant effect on wound healing activity in both normal and diabetic group of rats by minimizing the undesired consequences and shortening the period of wound healing.