Formulation and Evaluation of Bioadhesive Vaginal Gel for Mixed Vaginal Infections

The objective of our study was to formulate and evaluate bioadhesive gel for mixed vaginal infections. The combination of voriconazole and metronidazole were selected as model drugs for mixed vaginal infections. The bioadhesive gels were prepared with different ratios carbopol934. These bioadhesive gels was were characterized for Fourier transform infrared, content uniformity studies, in vitro bioadhesive studies, pH determination, spreadability test, extruability and in vitro release study in simulated vaginal fluid. The cumulative percent release of metronidazole from gels was found to be 55.10% and voriconazole was 68.90 % at the end of 7th hour. Among all the formulations F1 was found to be having good spreadability and viscosity with good in vitro release characteristics. All the performed experiments confirm the applicability of bioadhesive gels for the local treatment of mixed vaginal infections.