Oxidative Stress, Lipid Parameters and Paraoxonase1 Activity in Normoglycemic Hypertensive Patients

Hypertension is a common disease and is an important cause of morbidity and mortality worldwide. Occurrence of oxidation and peroxidation is one of the unfavorable consequences of hypertension on molecular systems. Large epidemiologic studies have demonstrated that subjects with hypertension have a marked increase in the prevalence of hypercholesterolemia, diabetes, hypomagnesemia, hypertriglyceridemia.  Paraoxonase1(PON1),an HDL bounded enzyme, protects LDL from oxidative stress by destroying biologically active phospholipids . Human serum PON1 activity was shown to be inversely related to the risk of cardiovascular diseases, and low PON1 activities were observed in atherosclerotic, hypercholesterolemic and hypertensive patients .