Hypothesis on Novel Bioflavonoid Formulations towards Treating Diabetes Mellitus

Bioflavonoids are the principle component of most of the plant species and are found be abundant. All most all of these flavonoidal components have the potential to control the blood glucose level. There has been limited research works performed on to these flavonoids, because of its low solubility and bioavailability, its utilization is rarely pronounced. However, exploring the areas of utilization of these flavonoids, by enhancing their solubility and bioavailability by suitable method like nanonizing the flavonoids using biodegradable polymers as formulation have the great advantage in treating diabetes. By the way the fullest potential of flavonoids would be explored in treating diabetes safely. We suggest that implementing the nanotechnology to convert the natural bioflavonoids having antidiabetic potential like naringin, hesperidin, rutin, silibinin etc., into nanoparticles using biodegradable polymers would increase the activity of bioflavonoids. It may give the chance of utilizing such nanoformulation clinically to treat and alleviate the problems associated diabetes effectively.