Development and Optimization of Fast Dissolving Film of Losartan Potassium

The present work aims to prepare fast dissolving films of Losartan Potassium with purpose of developing rapid onset of action, which is very convenient for administration without using water. Fast dissolving films are meant to be dissolved in saliva and remain in oral cavity until swallowed. The films were prepared by solvent casting method and characterized by UV, DSC studies. The plasticizer concentration was selected on the basis of flexibility, tensile strength and stickiness of the film. In the present study polyethylene glycol was used as plasticizes. Fast dissolving films were evaluated for drug content and the drug loading capacity. The dissolution profile and folding endurance were found to be satisfactory. The disintegration time of formulation F3 film was lowest (30 sec), so they release drug faster than other formulations. A drug-excipients interaction was performed by DSC and FTIR; results were shown that there was no interaction between drug and excipients used. In vitro release mechanism was evaluated by subjecting  the dissolution data to various kinetic models and the drug release was found to best fit the Korsemeyer-peppas model. Hence it is concluded that Losartan Potassium fast dissolving films are successfully developed and evaluated. Key Words: Fast dissolving films, Losartan Potassium, Solvent casting method, Hypertension