Antiulcer activity of Aqueous Alcoholic Extract of Leaves of Prenanthes Sarmentosus (AAPS) on Male Albino Rats

ABSTRACTUlcer can get developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred as peptic ulcers. This Prenanthes Sarmentosus leaves were used for reducing gastric irritation by people. This study was performed to avoid folklore belief.  The present study was carried by pylorus ligation, aqueous alcohol induced ulcer models in albino rats. The antiulcer activity of AAPS (150, 300 mg/kg p.o. for 10 days) was compared with standard drug (Omeprazole 0.5 mg/kg body weight). In pyloric ligation induced ulcer model, the studied parameters were gastric volume, pH, total acidity, free acidity, and ulcer index were determined for observing the severity of ulcers. In this study the volume of gastric content, total/free acidity was significantly decreased at p <0.05 and p <0.01 and pH of the gastric juice was significantly increased at p <0.05 and p <0.01 in AAPS treated groups as compared to control group. All the doses of AAPS showed dose dependent antiulcer effect as well as significant (p <0.05 and p <0.01) reduction in the ulcer index as compared to control group in all the experimental models. Keywords: Antiulcer effect, Pylorus ligation, Ulcer index