Evaluation of the acute toxicity and hemostatic properties of the aqueous extract of Cola cordifolia seeds.

ABSTRACTCola cordifolia is a plant whose seeds are rich in nutrients and bioactive compounds. This plant is used in traditional medicine to treat certain ailments and prevent certain metabolic diseases in order to enhance its value. Objective of this study was to evaluate the toxicity and hemostatic effect of the aqueous extract of Cola cordifolia seeds with a view to its valorization in the dietary and medicinal fields. Seeds were fermented for 6 days then dried for 15 days in the sun. Flour obtained was used to obtain the aqueous extract. Acute toxicity of the extract was evaluated at doses 300 mg/Kg bw and 2000 mg/Kg bw on rats. Subsequently, the hemostatic properties were evaluated. Acute toxicity results showed that Cola cordifolia seeds are not toxic at a dose of 2000 mg/Kg bw. Extract caused an increase in the weight of rats by 10.34 g and 9.34 g respectively at doses of 300 mg/Kg and 2000 mg/Kg bw. Aqueous extract reduced activated partial thromboplastin times from 44.4 to 18.6 seconds and prothrombin times from 6.5 to 4.5 seconds. Aqueous extract of Cola cordifolia promotes blood coagulation by the intrinsic and extrinsic pathways. Keywords: Acute toxicity, hemostatic, aqueous extract, Cola cordifolia