Evaluation of the Liver Toxicity and Nephrotoxicity of Creatinor, a Natural Recipe Used in the Treatment of Renal Failure in Côte d'Ivoire

ABSTRACTCreatinor is a natural recipe used in Côte d'Ivoire by traditional therapists to treat kidney failure. However, its toxicity has not yet been scientifically studied. The aim of this study is to assess the safety threshold of Creatinor use in mice and the toxic potential of this substance on the kidneys and liver of healthy rats. The acute oral toxicity study of Creatinor, in accordance with OECD 423 recommendations, shows that this substance is non-toxic in mice. The sub-acute toxicity study of Creatinor in healthy rats, in accordance with OECD guideline 407, showed that doses of 100 and 200 mg/kg bw caused, in a dose-dependent manner, decreases in the relative weights of the kidneys and liver of treated rats and, from the 21st day of treatment, increases in the levels of creatinine, urea, ALAT and ASAT. Creatinor also induced disorganisation of the histological structures of the kidneys and liver, with tissue necrosis. Creatinor, administered to healthy rats over a long period at doses of 100 and 200 mg/kg bw, is said to have nephrotoxic and hepatotoxic effects. At 200 mg/kg bw, these effects were more marked and more precocious, with adverse effects on body development. On the other hand, Creatinor at 50 mg/kg bw has no effect. Key words: Creatinor, toxicity, nephrotoxicity, hepathotoxicity, renal failure