Modification and Physical Characterization of Hupu Gum As A Carrier In Solid Dispersion Containing Clopidogrel Bisulphate

The objective behind this study was to enhance the solubility of clopidogrel bisulphate by solid dispersion technique and also to modify, evaluate and compare desired properties of carriers for solid dispersion. The melting point, swelling index, viscosity, bulk density, tapped density, angle of repose, water retention capacity were evaluated for plain and modified Hupu gum (MHG). The plain and modified Hupu gum was also characterized by differential scanning calorimetry and X-ray diffraction technique for physical interaction and crystallinity respectively, the comparative evaluation of plain and modified Hupu gum highlighted that the modified Hupu gum shows more desirable properties for preparation of solid dispersion. It concludes that modification of natural gums by heating at different temperature is one of the best techniques to acquire desired properties of carrier. Solid dispersion was prepared by Gel entrapment technique using and MHG in the ratio 1:1, 1:2 and 1:3 respectively. Solubility of pure Clopidogrel bisulphate was determined and compared the same with solid dispersion. Finally it was observed that enhancement in solubility of Clopidogrel bisulphate was obtained using MHG and drug in 1:2 ratio.