Development and Evaluation of Push Pull Osmotic System of Isoxsuprine Hydrochloride

The aim of present study was to design and evaluate push pull osmotic pump-based drug delivery system for controlled release of Isoxsuprine hydrochloride for peripheral and cerebral vasodilation. Core tablets were prepared by direct Compression method. Effects of different variables like amount of osmogen, orifice size, coating thickness and dissolution media were studied on release profile. It observed that the combination of PEO 100000 and PEO 300000 give the desired drug release. On increasing the amount of osmogen, the release of drug was found to be increased. On comparison of f2 value no significant effect of pH of dissolution medium, agitation rate was observed but it was observed that the coating thickness decrease it shows the faster drug release and increase in orifice size also increases the drug release.  It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance.