Preparation and Evaluation of Donepezil Loaded Nanoparticles

The purpose of the present study was to formulate and evaluate donepezill loaded nanoparticles for effective treatment of Alzheimer’s disease. Drug loaded nanoparticles was prepared by using modified nanoprecipitation technique, for this Ethyl Cellulose was selected as polymer in different ration with drug. The prepared nanoparticles were then subjected to several evaluation parameters like measurement of particles size, zeta potential, surface morphology, surface entrapment and drug content, in vitro dissolution study and stability study. Experimental results revealed that % yield was in range of 33.5% to 40.83% and drug entrapment was 70.003% to 86.8%. Particle size evaluation clearly state that prepared formulation within nano range (61.21 to 265.6 nm). Zeta potential value was find in the range of -32.9 to -17.4 mv and surface morphology study indicate smooth surface without fracture. In vitro release study shows that drug was released at a control rate and release rate depends on polymeric concentration. By kinekic study it was observed that zero order model is dominant for all five formulations and in all cases a super case II transport mechanism is dominant. After comparing all the evaluation parameter, formulation F4 was selected as optimized formulation and subjected for stability study which indicate that optimized formulation was stable. From this experiment it was clearly concluded that Donepezil Hydrochloride (model drug) can be successfully delivered to brain by preparing the nanoformulation at a control rate.