A. Kottai Muthu1* and Mohammed Ibrahim

The study was designed to examine the in-vitro antioxidant activities of various extracts of aerial parts of Chomelia asiatica. The antioxidant activity was evaluated by total antioxidant  activity, FRAP  with reference standard ascorbate respectively and estimate the amount of total flavonoids. The ethyl acetate extract of Chomelia asiatica was found to more effective in the total antioxidant activity. The IC50 of the ethyl acetate extract of Chomelia asiatica and ascorbate were found to be 260µg/ml and 480µg/ml respectively. An IC50 value was found that ethyl acetate extract of Chomelia asiatica is more effective in scavenging superoxide radical than that of methanol and petroleum ether extract. But when compare to the all the three extracts with ascorbate (standard), the ethyl acetate extract of the Chomelia asiatica showed the similar result. In addition, the ethyl acetate extract of Chomelia asiatica was found to contain a noticeable amount of total flavonoids, which play a major role in controlling antioxidants.  It is concluded that a aerial parts of ethyl acetate extract of Chomelia asiatica, which contains large amounts of flavonoids compounds, exhibits high antioxidant and free radical scavenging activities. These in vitro assays indicate that this plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.