Birendra Shrivastava

The implants, which are to be implanted under the skin (usually of the thigh or abdomen) with a special injector or by surgical incisions. Implants, are considered as a useful drug delivery system especially in chronic disorders. Literature survey revealed that numerous studies have been conducted on subcutaneous Implants to investigate use of different polymers for controlling the drug release for prolonged therapy, the pharmacokinetics and pharmacodyanamics of subcutaneous Implants, the safety of the polymers. In this investigation, it was planned to prepare implants of Lornoxicam, the NSAID by using gelatin as polymer and glycerin as a plasticizer, under aseptic conditions. The implants weighing 10 mg were hardened with Formaldehyde. The formulated implants were evaluated for thickness, wt variation, drug content uniformity, free Formaldehyde, drug polymer interaction and sterility. In vitro drug release studies were conducted in phosphate buffer pH 7.4. The stability studies were carried out at ambient temperature for 3 months.