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Diabetes, considered a major global public health issue, is often associated with dyslipidemia. Given the limitations of conventional treatments, people are showing increasing interest in medicinal plants. Thus, Rauvolfia vomitoria has several pharmacological properties, including antihypertensive and potentially antidiabetic effects. This study aims to evaluate the effect of repeated oral administration of EARv on the lipid profile over a six-month treatment period. Rauvolfia vomitoria roots were harvested, stripped of their bark, and then processed into an aqueous extract by maceration. Eighty healthy rats were divided into four groups (T, A, B, C) of 20 rats each, with 10 males and 10 females per group. Rats in group T received distilled water, while those in groups A, B, and C received EARv extract at doses of 500, 700 mg/kg body weight (b.w), and 1,000 mg/kg b. w, respectively, administered orally for six months at a rate of 2 mL/100 g b.w daily. Using serum from blood samples collected to measure total cholesterol, HDL cholesterol, and triglycerides. The results show that the aqueous extract of Rauvolfia vomitoria significantly reduced total cholesterol levels in a dose-dependent manner; it also led to an increase in HDL cholesterol levels and a significant reduction in triglycerides. EARv could represent an interesting therapeutic alternative for the management of diabetes and its metabolic complications. Keywords : Aqueous extract of debarked roots- Rauvolfia vomitoria- Lipid profile-Cholesterols -Triglycerides

ABSTRACTAccording to WHO cardiovascular disease (CVD) is the major cause of death in the worldwide. In India too, it has gone through a drastic lifestyle modification from traditional to western one and adapting sedentary lifestyle, consequently prone the people for CVDs. The present study was undertaken to identify the high risk individuals for CVDs in the next 10 years by using the cardiovascular risk assessment tools such as FRS and SCORE and recommendation of lifestyle modification and initiation of pharmacotherapy. A prospective observational study was conducted in patients with all possible risk factors (age, sex, high blood pressure, high HDL, TC, Smoking, and Obesity) for CVD over a period of six month in a tertiary care hospital. A total numbers of patients selected for the study was 90 among, 49 were males and 41 were females. The patients were categorized in to different risk groups. According to FRS tool, 35.5% individuals were at high risk and with SCORE tool, it was 41.1%. Whereas 33.3% individual who were under the high risk for CVDs by both the tools. The individuals’ lies between mild to moderate risk for CVDs were recommended for lifestyle modification to attenuate the triggering risk factors. Whereas high risk individual by both the FRS and SCORE tools were recommended for lifestyle modification along with pharmacotherapy in order to keep the risk factors under control. Keywords: Cardiovascular diseases; Risk factors; Assessment tools; Primary prevention.