Ezejindu D N

Guava leaves are among the herbs thought to be safe because they are natural yet herbs may contain hundreds of components that causes ill effects directly or through interaction with orthodox drugs. This work is aimed at investigating the histological effects of guava leaf extract on the liver of adult wistar rats. Twenty wistar rats weighing between 160 to 300g were used for the study. They were divided into four groups of five animals each. Group A served as the control and received only distilled water. The experimental groups B, C and D. received oral doses of 250mg/kg, 500mg/kg and 750 mg/kg of guava leaf extract respectively for fourteen days. The animals were sacrificed using, chloroform vapor inhalation method and dissected. Liver tissues were removed, weighed, trimmed down and fixed in 10% formal saline for histological studies. There were no histological alterations in the liver cell of the experimental groups compared with the control.