Pooja Manohar Arane

Excipients are components of a finished drug product other than the active pharmaceutical ingredient (API) and are added during formulation for a specific purpose.  In contrast to active ingredients, minor components of an excipient may have significant impact on its pharmaceutical performance. They are included in dosage forms to aid manufacture, administration or absorption. Excipients as like other active pharmaceutical ingredients need to be stabilized and standardized. They act as protective agents, bulking agents and can also be used to improve bioavailability of drugs in some instances. Specific excipients are best suited for a particular dosage form; the selection criterion for excipients and various interactions that an excipient can undergo during its course of stay in formulation has been discussed in this review.

There are several requirements for the safe and effective delivery of therapeutic agents for human use. Drug permeation to the normal regions of the body is the main drawback of conventional Drug delivery system. To avoid unwanted side effects of drug the approach like targeted drug delivery is preferred. In particular, carrier drug delivery system posses some structures which are attached the drug molecule for targeted delivery. Layer-by-Layer approach also offers a delivery of drug in a targeted fashion to avoid its unintentional effects on normal tissue. LbL self-assembly systems involve simple alternative adsorption of oppositely charged polyelectrolytes on core materials. Here, in this review we have discussed the latest findings from research into LbL systems, with special emphasis on drug delivery systems.