Purushotham K. Rao

Psoriasis is most frequently affects the skin of the elbows, knees, scalp, lumbosacral areas. It is the typical lesion well-demarcated, pink to salmon-colored plaque covered by loosely adherent scales that are characteristically silver white in color. Several topical therapies are available for the treatments of Scalp psoriasis like emollients, keratolytics, corticosteroids, tar, anthralin, vitamin D analogues and retinoids. .Currently available medications such as ointments and solutions are often greasy, sticky, odorous, difficult to apply, require frequent application, and are expensive causes poor patients compliance. In proposed work it is planned to prepare cream formulations of non-greasy and water removable, and improve patient’s compliance. This cream is o/w emulsion based formulation contain suitable combination of oil phase and aqueous phase along with preservatives, was prepared and subjected to various physiochemical parameters like drug content, pH, spreadability, tube extrudability, viscosity and IR studies. In-vitro drug release was carried out in phosphate buffer (pH 7.4) and compared with marketed formulation. Stability studies of formulation were also done at ambient temperature (30oC&40 oC) for the period of six months as per ICH guidelines. The formulations were subjected for primary skin irritation test in rabbits, guinea pigs, and healthy human volunteers for 72 hours and observed for any skin rashes, inflammation, itching, or redness. Drug content, pH, Spreadability, Tube extrudability of the formulation was found to be 95.47%, 7.2, 12.28gm.cm/sec, 96.14% respectively. From rheogram it is concluded that formulation shows pseudoplastic flow property. From our study it is revealed that salicylic acid  cream formulation should be useful for treatment of scalp psoriasis.