S. Malathi

ABSTRACTSimple, rapid, accurate and economical method has been developed for the simultaneous Estimation of cefpodoxime proxetil and Clavulanic acid in a synthetic mixture. The linearity was observed in the concentration range of 35 to 63 µg/ml for cefpodoxime proxetil and 10 to 18 µg/ml for Clavulanic acid. The method is based on the simultaneous equations, absorbance of both the drugs were determined at 232 nm (? max of cefpodoxime proxetil), and at 269 nm (? max of Clavulanic acid). The method was validated in terms of accuracy and precision. The Proposed method was found accurate, reproducible and economical for the routine analysis of both the drugs in synthetic mixture. Keywords: Cefpodoxime Proxetil, Clavulanic acid, UV spectroscopic analysis, Simultaneous Equation.

A new, rapid sensitive, simple and cost effective UV method was developed for the estimation of balofloxacin in bulk as well as in pharmaceutical formulations. The absorbance of balofloxacin was measured in 0.1N sodium hydroxide at new wave length (λmax 290). The linearity range was found to be 1-9 μg/ml.The method was tested and validated for various parameters as per ICH specification. The result demonstrates that the developed procedure is accurate, precise and reproducible. Proposed method is applicable for the estimation of balofloxacin in different dosage forms and results are in good agreement with label claim. Key words: Balofloxacin, 0.1N Sodium hydroxide, UV method.