Santosh H Pomaji

Herbal medicine has become an item of global importance both, medicinal and economical. The present research has been undertaken with the aim to formulate the herbal gel containing Plumeria alba extract for skin disease. The gel formulation was designed by using Plumeria albaleaves extract & various gelling agents viz: Carbapol 974P, Pectin, Aloe Vera gel, Ocimum Basilicum& Glycerin, propylene glycol, methyl paraben, propyl paraben in required amount of distilled water. The physicochemical Parameters of all formulations were determined. Drug-excipients compatibility studies were confirmed by carrying out FT-IR study. In-vitro drug release in phosphate buffer pH 7.4 and Diffusion study through cellulose membrane, and also Cadaver skin using a Franz diffusion cell, were performed. Stability studies have been carried out as per ICH guidelines for 3 months. It was observed that all the formulations showed good viscosity and Spreadability. In Vitro Drug release studies reveal that F5 and F7 formulations show  87.97 % and 84.29 % drug release respectively and permeation studies done with cadaver skin affirmed that  F5 and F7 formulation shows 85.32 % and 73.32 drug release respectively. The stability study revealed no significant difference between before and after storage. Overall result indicates that from that the combination of ocimum basilicum seed mucilage gel with natural or synthetic polymer can increase the drug release and stability of gel formulations containing Plumeria alba leaves extract.