Shetkar Madhav

Bryophyllum pinnatum belongs to the family crassulaceae  was widely used in traditional medicine especially in the tropical areas like in tropical Africa, tropical America, India, China, and Australia. Is a perennial herb grows 3-5 feet tall, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell like pendulous flowers. It is widely used in traditional medicine for the treatment of variety of ailments like anthelmentic, immunosuppressive, hepatoprotective, antinociceptive, anti-inflammatory and antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity and analgesic, anticonvulsant, neuropharmacological and antipyretic. It is well known for its haemostatic and wound healing properties. This review covers detailed ethnopharmacology, Phytochemistry and bioactivities of Bryophyllum pinnatum. A number of active compound groups including alkaloids, triterpenes, lipids, flavonoids, glycosides, bufadienolides, phenols and organic acids have been covered. The present review was designed to highlight the chemical constituents and pharmacological effects of Bryophyllum pinnatum.

Aceclofenac, a non-steroidal anti-inflammatory drug, has been used in the treatment of rheumatoid arthritis and osteoarthritis. In order to decrease the gas triculcerogenic effects, aceclofenac gels have been developed. This study was conducted to develop agel formulation of aceclofenac using four types of gelling agents: carbopol, Triethanolamine, Ethanol (99.9 %) and Polyethylene glycol. Effect of penetration enhancer (propyleneglycol) on the release has been studied. The gels were evaluated for physical appearance, rheological behavior, drug release and stability. The drug release from all gelling agents through a rat skin for diffusion study was evaluated using Keshary-Chien diffusion cell. All gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability and pH value. Among all the gel formulations, carbopol showed superior drug release than followed by Ethanol (99.9 %) and Polyethylene glycol and Sodium hydroxide. Drug release decreased within crease in polymer concentration. Drug release was not linearly proportional with the concentration of penetration enhancer or co-solvents. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for three months at ambient conditions.