Siva S

A simple, cost effective and reproducible UV-spectrophotometric method has been developed and validated for the assay of Tolterodine in pure and dosage forms. This assay is based on measurement of absorption at maximum wavelength of 282nm. Beer’s law of this proposed method was obeyed in the concentration range of 60-120μg/mL with regression equation of y = 0.0068x-0.0117 and with correlation coefficient of 0.9988 respectively. The percentage recovery of tolterodine ranged from 99.93- 100.37 in pharmaceutical dosage form. The results of the analysis for linearity, accuracy (recovery), precision and specificity were validated statistically and by recovery studies in accordance with ICH norms.

Paediatric patients require special consideration from health professionals in terms of drug interactions, as they react to drugs differently from adults. To provide better treatment by screening potential drug interactions, to Minimise the unnecessary use of non prescription medications by providing counselling. A prospective observational study was conducted in paediatric patients of a government general hospital. The study included patients between 0 and 12 years old, containing three or more drugs excluding topical drugs in their prescriptions. The analysis of interactions in prescribed drugs was done using Micromedex program. Based on the interactions found an analysis was performed on their relevance to the patients current situation, and after that, the medical teams were informed using the criterion service form of the pharmaceutical unit of the hospital. A total of 150 patients were included and 450 drugs were analyzed in the study. A mean value of 3 drugs per patient was observed during the study. In total, 216 drug interactions were found, which corresponds to 2.08 interactions per prescription. Among them, Ampicillin and Gentamicin was found in 65 prescriptions. Mild drug interactions are more but these are potential interactions. The presence of drug interactions is major risk in hospitalized patients. This study highlights the need for screening prescriptions for potential drug-drug interactions by utilization of computer programs, the pharmacist presence in the multidisciplinary team to minimize the occurrence of possible adverse drug reactions.