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American Journal of Pharmacy and Health Research

📢 Latest Update: Call for Papers for a Peer Reviewed Open Access Pharmacy Journal with Fast Publication

📢 Latest Update: Call for Papers for a Peer Reviewed Open Access Pharmacy Journal with Fast Publication

Volume 10, Issue 11 - 2022 (November 2022 Issue 11)

Volume 10 Issue 11 Cover

Issue Details:

Volume 10 Issue 11
Published:Invalid Date

Editorial: November 2022 Issue 11

Welcome to the 2022 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr H J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 2 of 2 articles
Research PaperID: AJPHR1011001

Metformin affects alternative splicing of the estrogen receptor alpha gene in breast cancer cells

Yoshihiro Harada, Tomoko Tanaka, Yuriko Hamaguchi, Yuta Horita, Masayoshi Mori, Yusuke Murata, Munechika Enjoji, Kenji Ohe

ABSTRACTMetformin ameliorates insulin resistance and reported to have prophylactic potential in breast cancer. The estrogen receptor-alpha gene is known to be alternatively spliced to the ER?46 isoform with decreased expression in tamoxifen-resistant breast cancer cells. We show here that metformin had a differential effect on its alternative splicing in MCF-7 and its tamoxifen-resistant derivative, TAMR1 cells. Metformin altered the tamoxifen-induced expression of ER?46 and treatment of cell-transplanted nude mice showed decreased tumor weight only in TAMR1 cell tumors. This is the first report to show metformin specifically involved in alternative splicing of genes in breast cancer cells. Keywords: Estrogen receptor-alpha (ER?), estrogen, tamoxifen, metformin

Estrogen receptor-alpha (ER?)estrogentamoxifenmetformin
105,295 views
31,620 downloads

Contributors:

 Yoshihiro Harada
,
 Tomoko Tanaka
,
 Yuriko Hamaguchi
,
 Yuta Horita
,
 Masayoshi Mori
,
 Yusuke Murata
,
 Munechika Enjoji
,
 Kenji Ohe
Research PaperID: AJPHR1011002

Leiomyomatous polyp presenting as Intussusception in an elderly female - A Rare Case Report

Bushra Siddiqui, Gouthami N, Saqib Ahmed, Zeeshan Nahid, Uttar Pradesh

ABSTRACTIntussusception is quite common in the gastrointestinal tract and that too in the paediatric population though the aetiology is mostly idiopathic (90%). While in adults it is rare and is usually caused by an identifiable underlying lesion mainly neoplasm (70-90%) which usually acts as a lead point. It has a non-specific clinical presentation with a limited role of history and examination in the final diagnosis and Computed tomography is considered the gold standard investigation in establishing the diagnosis. We present an unusual case of jejuno-jejunal intussusception which was caused by a leiomyoma polyp. Thus an Exploratory laparotomy was done, resecting the polyp with the jejunal segment and the diagnosis was confirmed by histopathological examination. Keywords: Intussusception, Jejunal, Leiomyoma, Histopathology

IntussusceptionJejunalLeiomyomaHistopathology
105,058 views
31,579 downloads

Contributors:

 Bushra Siddiqui
,
 Gouthami N
,
 Saqib Ahmed
,
 Zeeshan Nahid
,
 Uttar Pradesh
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