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American Journal of Pharmacy and Health Research

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Volume 6, Issue 2 - 2018 (February 2018 Issue 2)

Volume 6 Issue 2 Cover

Issue Details:

Volume 6 Issue 2
Published:Invalid Date

Editorial: February 2018 Issue 2

Welcome to the 2018 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: AJPHR602001

Comparison of Outcomes of Two Different Treatment Methods In The Management of Diabetic Foot Ulcer

M.V.R. Harsha Vardhan, Y. Suraj Varma, S. Parimalakrishnan, Junior Sundresh

ABSTRACTThe aim of this study was to compare the outcomes of surgical versus non- surgical treatment in the management of Diabetic Foot Ulcer. A Prospective Observational Study which was carried out in the Department of Surgery of Rajah Muthiah Medical College Hospital a tertiary health care hospital in Chidambaram, Cuddalore District, Tamilnadu in the period of November 2016 to April, 2017 (6 months). The patient demographic, disease, ulcer size, drugs and treatment prescribed were collected in a specially designed data collection form which also included bacterial culture tests. Upon enrolment for the study 65% (39) of the patients diagnosed for diabetic foot were male and 35% (21) were female. The demographic classification suggests that diabetic foot incidence has increased upon ages of people ranging between the mean ages of 45+/- 5 years to 60+/-5 years. The bacterial distribution over the patients showed that, out of which Escherichia coli (28.3%) and Staphylococcus aureus (15%) are the most common bacteria. The outcomes mainly depend upon the grading of infection and ulcer size. The superficial ulcers can be treated more effectively with antibiotics and regular dressings, whereas the deep ulcers and gangrene should be intervened with surgical procedures. The assessed study reports that clinical pharmacist intervention by patient education and medication counselling creates a significant influence in medication adherence Keywords: Diabetic foot ulcer, surgical treatment, Non-surgical treatment, management

Diabetic foot ulcersurgical treatmentNon-surgical treatmentmanagement
82,148 views
24,709 downloads

Contributors:

 M.V.R. Harsha Vardhan
,
 Y. Suraj Varma
,
 S. Parimalakrishnan
,
 Junior Sundresh
Research PaperID: AJPHR602002

Inhibition of Formation of Fructose Induced Advanced Glycation End Products by Momordica chochinchinensis

Swathi Putta, Eswar Kumar Kilari

ABSTRACTThe present study evaluates the antioxidant potential of hydro alcoholic pericarp extract of Momordica chochinchinensis (HAPMC) using different model systems. To establish the link between glycation and oxidation processes, the HAPMC extract has been evaluated for its in vitro radical scavenging  activity against superoxide, hydroxyl, hydrogen peroxide, nitric oxide, ferric and ABTS+ radical and antiglycation activities like the inhibitory activities on bovine serum albumin (BSA) and as well as protein oxidation markers including protein carbonyl formation (PCO). The results indicated that the HAPMC possesses the highest antioxidant potential against superoxide, hydroxyl, hydrogen peroxide, nitric oxide, ferric radical and ABTS+ radical. The HAPMC extract at different concentrations (10–250 µg/ml) has significantly quenched the fluorescence intensity of glycated BSA and the glycoxidation measured in terms of advanced glycation end products (AGEs). Furthermore, the study demonstrated that the inhibitory effect of HAPMC extract in preventing oxidative protein damages including effect on PCO formation, which are believed to form under the glycoxidation processes. These results clearly demonstrate that the HAPMC, owning to its antioxidant content, is capable of suppressing the oxidative stress, carbonyl stress and formation of AGEs and protein oxidation in vitro. Keywords: Advanced glycated end products, Oxidation, Momordica chochinchinensis

Advanced glycated end productsOxidationMomordica chochinchinensis
82,112 views
24,668 downloads

Contributors:

 Swathi Putta
,
 Eswar Kumar Kilari
Research PaperID: AJPHR602003

Social Anxiety and Problematic Internet Use among University Students

Rabina Debbarma, G. Umadevi

ABSTRACTThis study was conducted to find out the relationship between social anxiety and problematic internet use among university students. It was also tried to find out the difference between demographic variables like gender and locality. 200 university students were selected from Tripura University, in Tripura State through simple random sampling technique. Problematic Internet Use Questionnaire (Tatcher & Goolam, 2005) and Social Anxiety Questionnaire for Adults (SAQ-A30) developed by Callallo, Salazar, Irurtia, Arias and CISO-A Research Team, 2010 were used for data collection. The obtained results revealed that there is a positive relationship between problematic internet use and social anxiety. Males were found to have more social anxiety and problematic internet use. Further it is found that there is no significant different between Problematic Internet use on the basis of locality, but were found significant different social anxiety. Keywords: Problematic Internet Use, Social Anxiety, Gender and Locality

Problematic Internet UseSocial AnxietyGender and Locality
82,519 views
24,677 downloads

Contributors:

 Rabina Debbarma
,
 G. Umadevi
Research PaperID: AJPHR602004

Development and Validation of High Performance Liquid Chromatography for the Determination of Domperidone and Esomeprazole in Their Pharmaceutical Formulation

Ahmed S. A. Ali, Omnia I. M. Ali, Abdel Fattah B. Farag, Maged F. Abdel Khalek

ABSTRACTA new precise, accurate, robust and stability indicating high-performance liquid chromatographic method has been developed and validated for the simultaneous estimation of domperidone (DOM) and esomeprazole (ESO) in their pharmaceutical formulation. The proposed method carried out on Waters Symmetry C18 column (250 mm x 4.6 mm, 5.0 µm particle size) using an isocratic elution technique at a column temperature of 30 ?C. The mobile phase was a mixture of 0.01M sodium acetate buffer: methanol (45:55 v/v) and it was adjusted to pH 4.5 using glacial acetic acid with a flow rate of 1 mL/min and an injection volume of 20 µL. The retention times were 3.7 and 5.0 min with UV detection at 290 nm for DOM and ESO, respectively. The proposed method was linear over the concentration ranges of 0.04-60.0 and 0.08-120.0 µg/mL for DOM and ESO, respectively. Limit of detection and limit of quantitation values were 0.48 and 1.44 µg/mL for DOM and 0.47 and 1.43 µg/mL for ESO, respectively. The method also exhibited good levels of recovery from 100.23% to 101.59% for DOM and from 99.74% to 101.57% for ESO. From the validation study, it was found that the method was specific, rapid, accurate and reproducible. The high percentage of recovery and low relative standard deviation confirm the suitability of the method for routine pharmaceutical analysis of both drugs separately or in their combined dosage form. Keywords: HPLC; Esomeprazole; Domperidone; Validation; Formulation.

HPLCEsomeprazoleDomperidoneValidationFormulation.
82,252 views
24,842 downloads

Contributors:

 Ahmed S. A. Ali
,
 Omnia I. M. Ali
,
 Abdel Fattah B. Farag
,
 Maged F. Abdel Khalek
Research PaperID: AJPHR602005

Antioxidant, Free Radical Scavenging and In Vitro Cytotoxic studies of Different Solvent Extracts from the Stem Bark of Bauhinia Variegata Linn.

Trupesh Pethani, Mayuri Thumar, Vishal Airao, Ashvin Dudhrejiya

ABSTRACTBauhinia variegata (Family: Fabaceae) is well-known medicinal plant used from the ancient era to till date for their medicinal values. The powerful biological activities as exhibited by plant flavonoids posed the need of determining their contents in B. variegata stem bark. In view of its wide use and its chemical compositions, this study was aimed at examining and comparative analysis of the antioxidant and anticancer activities of the different extracts of stem bark. Antioxidant activity of extracts was expressed as percentage of DPPH, super oxide and nitric oxide free radicals inhibition and expressed asIC50 values (?g/mL). Methanolic extracts of B. variegata showed the highest amount of and ?avonoid contents and reducing capacity whereas, chloroform and dichloromethane extracts of B. variegata showed pronounced cytotoxic effect against HCT-116, A549 and ethyl acetate extracts showed pronounced cytotoxic effect against Ovcer-5 human cancer cell lines. The order of antioxidant activity in B. variegata extracts displayed from higher to lower level as methanol, hydro-alcoholic, ethyl acetate, chloroform, dichloromethane and n-hexane extracts of stem bark of B. variegata. Commercial standards were taken as control showed highest antioxidant power in the present study. Chemical components of B. variegata have good antioxidant capacities and this species could be used as a potential source of new natural antioxidants. Keywords: Antioxidant; Bauhinia variegata; Cytotoxicity; Stem bark extract; Total flavonoids.

AntioxidantBauhinia variegataCytotoxicityStem bark extractTotal flavonoids.
82,514 views
24,799 downloads

Contributors:

 Trupesh Pethani
,
 Mayuri Thumar
,
 Vishal Airao
,
 Ashvin Dudhrejiya