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Volume 6, Issue 3 - 2018 (March 2018 Issue 3)

Volume 6 Issue 3 Cover

Issue Details:

Volume 6 Issue 3
Published:Invalid Date

Editorial: March 2018 Issue 3

Welcome to the 2018 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 4 of 4 articles
Research PaperID: AJPHR603001

Anti-Tubercular Activity of Indian Medicinal Plants – A Review

M. Indhumathi, A.Shanuvas

ABSTRACTTuberculosis is a bacterial infectious disease caused by Mycobacterium tuberculosis. It is highly infectious and opportunistic disease. The synthetic drugs for anti-tuberculosis effect have been prescribed for symptomatic control of disease but produce much adverse effect. Naturally obtaining medicinal plants are incomparable resources of Siddha. From thousands of years, medicinal plants provide a great hope to curing diseases. This review spotlights the effort on anti-tubercular plants, which are various source of literature. This paper provides the plant description, chemical constituents, evidence based pharmacological activity. This will motivate and provide a way for further researches on medicinal plants, possess potent anti- tuberculosis activity. Keywords: Tuberculosis, Anti-tubercular activity, Medicinal plants, Siddha.

TuberculosisAnti-tubercular activityMedicinal plantsSiddha.
82,707 views
24,731 downloads
DOI:
10.46624/ajphr.2018.v6.i3.001

Contributors:

 M. Indhumathi
,
 A.Shanuvas
Research PaperID: AJPHR603002

Liquisolid Technique : A Novel Approach For Enhancement of Solubility and Bioavailability

Jain Urvashi, Sohaney Nikita, Malviya Sapna

ABSTRACTLiquisolid strategy is otherwise called powder solution technology. It is the system which manages the solubility upgrade of inadequately solvent medications. As nowadays there are numerous medications in the market with poor solvency which prompts poor disintegration and bioavailability, so dissolvability is getting to be rate constraining component in the advancement of new medications. To defeat this issue there are numerous systems yet liquisolid strategy is most encouraging procedure which is talked about in this article. Liquisolid is for the most part made out of medication, non volatile solvent, carrier material, coating material, and disintegrant. In liquisolid strategy carrier and coating material which ought to be in the proportion of 20:1 is blended into the non volatile solvent and after that disintegrant is included and last material is packed into tablets. Henceforth, the liquisolid innovation permits the change of fluid frameworks into strong medication conveyance frameworks. Both quick and managed arrival of medication can likewise be accomplished with the assistance of liquisolid procedure. For sustained release of medication hydrophilic polymer like Hydroxy Propyl Methyl Cellulose can be the best choice. The motivation behind this article is to depict about the liquisolid strategy like basics, classification, preformulation examines, characterization, pre compression contemplates, detailing of tablet, post compression thinks about, points of interest, drawbacks, applications.Keywords: Liquisolid, bioavailability, dissolution, sustained release.

Liquisolidbioavailabilitydissolutionsustained release.
82,879 views
24,789 downloads
DOI:
10.46624/ajphr.2018.v6.i3.002

Contributors:

 Jain Urvashi
,
 Sohaney Nikita
,
 Malviya Sapna
Research PaperID: AJPHR603003

Anti Tubercular Drug Induced Liver Disease: A Case Report In A Tertiary Care Teaching Hospital

M. Jeevana Sravanthi, C.Veeravamsi, Y. Grace Nithya, P. Gowtham Kumar reddy

ABSTRACTTuberculosis is one among the serious public health challenge worldwide. Among broad range of drugs that are known to induce liver damage, hepatotoxic side effects are serious challenges in patients receiving Anti-TB medications.  First line agents that are used for treating this condition induce various adverse effects including liver injury, skin reactions, and gastrointestinal reactions. However in addition to individual risk factors like age, gender and  hypo albunemia, use of anti tubercular drugs in combination enhances the degree of toxicity as each drug possess varying degree of liver toxicity. Drug induced liver injury (DILI) is the most common and serious adverse reaction caused due to the use of ATT regimen that needs vigilant monitoring in preventing fatal complications. Here we present a case of hepato toxicity induced by use of ATT (Rifampicin 450 mg, Isoniazid 75 mg, Pyrazinamide 400 mg and Ethambutol 275 mg OD) for a period of one month later on which she experienced drug hypersensitivity reactions and altered liver function tests. The suspected ADR was probable ADR (Naranjo’s scale). Offending drug regimen was stopped and second line agents (SLE regimen) along with supportive care were given. Hence it is often essential that clinicians regularly evaluate patients for these conditions to prevent their emergence and progression.Keywords: ATT (anti tubercular therapy), DILI (drug induced liver injury), Hepato toxicity, Tuberculosis, SLE (streptomycin, Levofloxacin, Ethambutol)     

ATT (anti tubercular therapy)DILI (drug induced liver injury)Hepato toxicityTuberculosisSLE (streptomycinLevofloxacin+1 more
82,869 views
24,896 downloads
DOI:
10.46624/ajphr.2018.v6.i3.003

Contributors:

 M. Jeevana Sravanthi
,
 C.Veeravamsi
,
 Y. Grace Nithya
,
 P. Gowtham Kumar reddy
Research PaperID: AJPHR603004

Studies on Design and Development of Mouth Dissolving Film of Desloratadine

Vipul V. Jambukiya, Jayvadan K. Patel

ABSTRACTIn the present study, formulation of mouth dissolving film containing antihistaminic drug Desloratadine was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of allergy. The combination of drug with suitable polymers such as HPMC E-5 and HPMC E-15 helps in providing quick release of the drug. Mouth dissolving film was prepared by solvent casting method using PEG 400 as plasticizer. A 32 full factorial design was applied to an optimized the effect of independent variables like HPMC E-5 and HPMC E-15 on dependent variables like disintegration time, thickness and folding endurance of the film. The responses were analyzed using design of expert software and it was found that the concentration of HPMC E-5 and HPMC E-15 significantly affects on dependent parameters. The prepared optimized formulation showed minimum disintegration time (10s) and highest dissolution rate (99.02 ± 0.284 %). The two check point formulations were prepared as suggested by the software. All the predicted values of responses were found to be close to the observed values. Stability study shows that there was no significant change in physical appearance, disintegration time, thickness, drug content and In vitro drug release of the formulation. Mouth dissolving film is an innovative concept for quick release of the drug. Thus, allergy can be quickly treated by this formulation. Keywords: Mouth Dissolving film, Desloratadine, HPMC E-5, HPMC E-15, Test masking

Mouth Dissolving filmDesloratadineHPMC E-5HPMC E-15Test masking
82,841 views
24,913 downloads
DOI:
10.46624/ajphr.2018.v6.i3.004

Contributors:

 Vipul V. Jambukiya
,
 Jayvadan K. Patel

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