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📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

Volume 6, Issue 6 - 2018 (June 2018 Issue 6)

Volume 6 Issue 6 Cover

Issue Details:

Volume 6 Issue 6
Published:Invalid Date

Editorial: June 2018 Issue 6

Welcome to the 2018 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 4 of 4 articles
Research PaperID: AJPHR606001

Raoultella Ornithinolytica Urinary Tract Infections are on the Rise: A Case Report

Atif A. Katib, Bassem A. Dakkak, Husam A. Katib, Sara K. Alem

ABSTRACTCommunity-acquire urinary tract infection (UTI) with Raoultella ornithinolytica is rare, with only 36 cases have been reported in the literature. The case in hand reports a 29 yrs. old lady with pelvic inflammatory disease who suffered from bothering irritative lower urinary tract symptoms (LUTS) ten days after removing an intrauterine contraceptive device. Urine culture recovered the rare bacterium of Raoultella ornithinolytica. Based on the sensitivity result, the patient has been treated with levofloxacin antibiotic and has responded favorably. Keywords: Raoultella Ornithinolytica, Klebsiella, community-acquire UTI 

Raoultella OrnithinolyticaKlebsiellacommunity-acquire UTI
84,876 views
25,425 downloads
DOI:
10.46624/ajphr.2018.v6.i6.001

Contributors:

 Atif A. Katib
,
 Bassem A. Dakkak
,
 Husam A. Katib
,
 Sara K. Alem
Research PaperID: AJPHR606002

RP-HPLC Method Development and Validation for Simultaneous Estimation of Hydrocortisone and Acyclovir in Pharmaceutical dosage forms.

Ramavath Mohanbabu Naik, Syed Ahmed, G. Naveen kumar Reddy

ABSTRACTThe Chromatographic condition were successfully developed for the separation of Acyclovir and     Hydrocortisone by using Agilent C8 column (25 cm x 4.6 mm i.d., 5 ?). A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Hydrocortisone and Acyclovir from pharmaceutical formulation. The method was carried out on a C8 (25 cm x 4.6 mm i.d., 5 ?) column with a mobile phase consisting of Methanol: water (adjusted to pH 3.0 using o-phosphoric acid) in the ratio of 80:20 v/v. The retention time of  Hydricortusone and Acyclovir was 3.50 min and 6.00 min respectively with the flow rate of 1mL/ min. Eluents were detected at 254 nm.  The linear regression analysis data for the linearity plot showed good linear relationship with correlation coefficient value for Hydrocortisone and Acyclovir were R2=0.9995 and R2=0.9996 in the concentration range of 10-40µg. mL-1 , 20-80 µg. mL-1 respectively. The relative standard deviation for intra-day precision was lower than 2.0 %. The method was validated according to the ICH guidelines. The method was also found to be robust. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability. Keywords: RP-HPLC, Hydrocortisone, Acyclovir, Agilent , Mobile Phase, Retention time.

RP-HPLCHydrocortisoneAcyclovirAgilentMobile PhaseRetention time.
84,760 views
25,535 downloads
DOI:
10.46624/ajphr.2018.v6.i6.002

Contributors:

 Ramavath Mohanbabu Naik
,
 Syed Ahmed
,
 G. Naveen kumar Reddy
Research PaperID: AJPHR606003

In-Vitro Anticoagulant and Clot-Lysis Potential of Aqueous Extract of Datura Metel L.

Ashok A. Muchandi, Nitin S. Thorat, Suhas R. Mahanwar

ABSTRACTThromboembolic disorders affecting millions of people worldwide. Presently available anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation but having limited use due serious side effects. A medicinal herb Datura metel belongs to family Solanaceae, has been widely used in traditional medicine. In the present study, different concentrations (20-100 µg/ml) of aqueous extract of leaves of Datura metel was evaluated for in-vitro anticoagulant and clot lysis activity. The results showed that, there was concentration dependent increase in anticoagulant activity as a measure of increased prothrombin time activity. Similarly, there was concentration dependent increase in percentage clot lysis activity. A maximum 23.81% clot lysis activity was reported at concentration 100 µg/ml of extract. Thus, it was concluded that, aqueous extract of leaves of Datura metel has potential in-vitro anticoagulant and clot lysis activity and may be beneficial in the treatment of cardiovascular diseases. Keywords: Clot lysis, cardiovascular diseases, prothrombin time, anticoagulants, 

Clot lysiscardiovascular diseasesprothrombin timeanticoagulants
84,790 views
25,620 downloads
DOI:
10.46624/ajphr.2018.v6.i6.003

Contributors:

 Ashok A. Muchandi
,
 Nitin S. Thorat
,
 Suhas R. Mahanwar
Research PaperID: AJPHR606004

Formulation and Evaluation of Antimicrobial Activity of Topical Niosomal Gel of Erythromycin

Nettem Lalithajyotsna, Mohammad Sarfaraz Ali Ahmed, Mahendar choudary, Dr.vasudha Bakshi

ABSTRACTErythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. The drugs in the form of topical gels avoid gastro-intestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The main objective of the study is to formulate and evaluate the antimicrobial activity of erythromycin formulation for effective topical delivery of the drug. The antimicrobial activity of the erythromycin loaded gel is carried by cup-plate method and the zone of inhibition was noted. The current analysis demonstrates persistence release of drug, an increase in amount of drug maintenance into skin and enhanced permeation across the skin after entrapment of Erythromycin into niosomal topical gel. Keywords: Niosomes, Erythromycin, Antimicrobial activity, topical delivery, cup-plate method, Niosomal Gel and Skin Retention.

NiosomesErythromycinAntimicrobial activitytopical deliverycup-plate methodNiosomal Gel and Skin Retention.
85,191 views
25,519 downloads
DOI:
10.46624/ajphr.2018.v6.i6.004

Contributors:

 Nettem Lalithajyotsna
,
 Mohammad Sarfaraz Ali Ahmed
,
 Mahendar choudary
,
 Dr.vasudha Bakshi

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