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Volume 6, Issue 7 - 2018 (July 2018 Issue 7)

Volume 6 Issue 7 Cover

Issue Details:

Volume 6 Issue 7
Published:Invalid Date

Editorial: July 2018 Issue 7

Welcome to the 2018 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 6 of 6 articles
Research PaperID: AJPHR607001

Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy

Akila RM, Sneha Anna Saju

ABSTRACTNanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and  DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics. Keywords: biodegradable chitosan, nanoparticles, almotriptan malate,  mucoadhesion  

biodegradable chitosannanoparticlesalmotriptan malatemucoadhesion
85,505 views
25,563 downloads
DOI:
10.46624/ajphr.2018.v6.i7.001

Contributors:

 Akila RM
,
 Sneha Anna Saju
Research PaperID: AJPHR607002

Formulation and Optimization of In-Situ Buffered Formulation Containing Indomethacin In Combination With Pantoprazole

Preeti Khulbe*: Birendra Srivastava Pankaj sharma

ABSTRACTIn-Situ buffer formulation contain agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. Here this approach is used for making combination capsule formulation to reduce the side effects of Nonsteroidal anti-inflammatory drugs. Pantoprazole is an acid labile drug which is very useful for the prevention and treatment of NSAID related gastric ulcer, so to reduce its side effects this approach was used. In this Indomethacin is used as Nonsteroidal anti-inflammatory drugs. For this purpose, macroenvironment buffering method was used. Based on their acid neutralizing capacity the best buffering combination was selected. In this method immediate release excipients or superdisintegarnts (SSG & CCS) whereas rate retarding polymers (Guar gum, Xanthan gum & ethyl cellulose) were added in the formula.  Ex vivo permeation study was performed by using Non-everted intestinal sac method in selected optimized batch. For optimization full factorial 23 design was used along with mathematical models. Prepared optimized formulation was compared with marketed formulation. Final pH from optimized formulation was found to be 5 to 6. The prepared optimized capsule is having 98.86% immediate release of pantoprazole sodium sesquihydrate upto 30 min and 99.84% sustain release of indomethacin upto 12 hrs. The prepared formulation showed immediate release of stable pantoprazole sodium sesquihydrate (due to the presence of in-situ buffering agents inside the capsule) along with the sustained release Indomethacin with very less adverse effects. Keywords: Stable pantoprazole sodium sesquihydrate, sustained release, macroenvironment, Ex vivo permeation.

Stable pantoprazole sodium sesquihydratesustained releasemacroenvironmentEx vivo permeation.
85,456 views
25,600 downloads
DOI:
10.46624/ajphr.2018.v6.i7.002

Contributors:

 Preeti Khulbe*: Birendra Srivastava Pankaj sharma
Research PaperID: AJPHR607003

Design and Evaluation of Doxofylline Immediate Release Tablets

Bharathi Agirela, Nandini.Akula, Nikitha.Ponnam, Chandra Sekhar Naik.D

ABSTRACTDoxofylline a bronchodilator and anti-tussive is used for chronic obstructive pulmonary disease (COPD) and asthma that acts as phosphor diesterase inhibitor with minimum cardiovascular side effects due to low affinity foradenosine receptors (both A1 and A2) unlike theophylline and other xanthine derivatives. Doxofylline is water soluble and comes under biopharmaceutical classification class III with high solubility and low permeability. In this study an attempt has been made in development and to evaluate the formulation of Doxofylline tablets of 400mg and these compressed tablets were tested for friability, thickness, disintegration time, hardness, weight variation and assay. The formulation trial F4 was optimized considering the drug release profile and the disintegration time of tablets as they were very close to the reference product values. From this study, it may be concluded that for Doxofylline tablets, F4 stands as a successful formulation and can be manufactured with reproducible characteristics from batch to batch to match the release profile with the reference product. The in-vitro release of Doxofylline tablets was studied in 900 ml of distilled water as dissolution medium using an I.P dissolution paddle assembly at 100rpm and 37±2°C for 45min. Keywords: Doxofylline tablets, Micro crystalline cellulose, HPLC, Antiasthmatic

Doxofylline tabletsMicro crystalline celluloseHPLCAntiasthmatic
85,561 views
25,649 downloads
DOI:
10.46624/ajphr.2018.v6.i7.003

Contributors:

 Bharathi Agirela
,
 Nandini.Akula
,
 Nikitha.Ponnam
,
 Chandra Sekhar Naik.D
Research PaperID: AJPHR607004

A Case Report on Thiazide-type Diuretic Induced Fixed Drug Eruption

Rahul Rawat, Yogesh Joshi, Ankit Sharma

ABSTRACTFixed drug eruption (FDE) is one of the most common cutaneous adverse drug reactions in Indian patients. Chlorthalidone (CTD), a thiazide-type diuretic that inhibits distal convoluted tubule sodium and chloride resorption, is a commonly used oral antihypertensive. We are presenting a case of chlorthalidone induced FDE where a 75 year old hypertensive male admitted in hospital with complains of rashes associated with burning sensation on trunk, back and left arm after the administration of tablet chlorthalidone. FDE is believed to be a lymphocyte CD8-mediated reaction, wherein the offending drug may induce local reactivation of memory T cell lymphocytes localized in epidermal and dermal tissues and targeted initially by the viral infection. The initial treatment of FDE is discontinuation of the causative agent. Keywords: Fixed drug eruption, Chlorthalidone, Cutaneous adverse drug reactions

Fixed drug eruptionChlorthalidoneCutaneous adverse drug reactions
85,581 views
25,678 downloads
DOI:
10.46624/ajphr.2018.v6.i7.004

Contributors:

 Rahul Rawat
,
 Yogesh Joshi
,
 Ankit Sharma
Research PaperID: AJPHR607005

Harmful Effects of Alcohol On Essential Physiological Organs

Shahnawaz Ahmad Teli, Yogesh Joshi

ABSTRACTAlcohol abuse is one of major and increasingly attributable risk factor for mortality and morbidity worldwide. The underlying purpose of this review is to promote awareness and significance in relation to the effects of alcohol on various body systems especially on cardiovascular system, liver, adipose tissue, skeletal muscle, brain, water and electrolyte metabolism and endocrine system. Alcohol when used above the normal range can results in harmful consequences on different biological organs. Average volumes consumed and patterns and frequency of drinking are three dimensions of alcohol consumption that need to be considered in efforts to reduce the burden of alcohol-related harmful effects. To reduce such harmful effects, national policies need to be developed to keep track of alcohol consumption and its consequences, and to raise awareness amongst the public. It is up to both public and concerned governments to encourage debate and formulate effective public health oriented policies and measures in order to minimize the harm caused by alcohol. Keywords: Alcohol, consumption, harmful effects, awareness

Alcoholconsumptionharmful effectsawareness
85,744 views
25,721 downloads
DOI:
10.46624/ajphr.2018.v6.i7.005

Contributors:

 Shahnawaz Ahmad Teli
,
 Yogesh Joshi
Research PaperID: AJPHR607006

Pharmacological account of Hibiscus Sabdariffa Linn.

Sudhir S. Mulay

ABSTRACTHibiscus sabdariffa Linn. is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine. The plant is reported to contain proteins, fats, carbohydrates, flavonoids, acids, minerals and vitamins. The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer and antioxidant properties. The present paper is an overview on its pharmacological properties reported in the literature. Keyword: Hibiscus sadariffa, Antihypertensive, Anticancer, Antioxidant, Flavonoids etc.

Hibiscus sadariffaAntihypertensiveAnticancerAntioxidantFlavonoids etc.
85,854 views
25,823 downloads
DOI:
10.46624/ajphr.2018.v6.i7.006

Contributors:

 Sudhir S. Mulay

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