editor.ajphr@gmail.com
9409046853
e-ISSN: 2321-3647
logo

American Journal of Pharmacy and Health Research

LoginTrack

📢 Latest Update: Call for Papers for a Peer Reviewed Open Access Pharmacy Journal with Fast Publication

📢 Latest Update: Call for Papers for a Peer Reviewed Open Access Pharmacy Journal with Fast Publication

Volume 6, Issue 12 - 2018 (December 2018 Issue 12)

Volume 6 Issue 12 Cover

Issue Details:

Volume 6 Issue 12
Published:Invalid Date

Editorial: December 2018 Issue 12

Welcome to the 2018 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr H J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: AJPHR612001

Effect of Allium sativum on the Pharmacodynamics of Pioglitazone in Normal and Alloxan Induced Diabetic Rats

Rajasekhara Reddy T, Swathi P1 and Eswar Kumar K

ABSTRACTThe present study was carried out to study the herb drug interactions between the traditional medicine Allium sativum with conventional antidiabetic drug Pioglitazone in normal and diabetic conditions. Blood samples were collected from rats by retro orbital puncture at regular intervals of time 0, 1, 2, 3, 4, 6, 8, 10, 12 hr. The Pioglitazone and Allium sativum showed dose dependent reduction of blood glucose levels. The optimum blood glucose reduction was obtained at 10mg/kg of pioglitazone and 200mg/kg of Allium sativum in normal rats. The blood glucose levels were found to be decreased and insulin levels were increased significantly in both single and multiple dose combinations of Pioglitazone and Allium sativum both in normal rats (4hr) as well as in Alloxan induced diabetic rats (3hr) compared with the pioglitazone alone. Since the combination of Allium sativum and pioglitazone producing the significant synergistic action in producing hypoglycemia and anti hyperglycemia, care must be taken while prescribing the combination in clinical situation. Keywords: Pioglitazone, Allium sativum, Blood Glucose.

PioglitazoneAllium sativumBlood Glucose.
87,828 views
26,377 downloads
DOI:
10.46624/ajphr.2018.v6.i12.001

Contributors:

 Rajasekhara Reddy T
,
 Swathi P1 and Eswar Kumar K
Research PaperID: AJPHR612002

Pharmacological Evaluation of Ethanolic Extract of Leaves of Memecylon Kollimalayanum

G.Sekar, T.Venkatachalam, P.Kalaisevi, and R.Ramprasad

ABSTRACTThe present studies emphasize the investigation on ethanolic extract of Memecylon kollimalayanum. (Family- Melastomataceae) leaves for its anti-diabetic activity in animal model. Alloxan induced diabetes model was used for the study. The pharmacological and acute toxicity studies of ethanolic extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed upto 2000mg/kg of body weight. The standardized doses of 250, 500, 1000 and 2500 mg /kg 1 body weight of the extract were administered orally to normal and diabetic rats in order to define its hypo-glycemic potential. Results The Biological dose of extract Memecylon kollimalayanum dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity. This study shows that flavanoids present in this extract may be possibly responsible for the antidiabetic activities respectively. Histopathological studies on isolated pancreas revealed that ethanolic extract of Memecylon kollimalayanum   reversed the changes which produced due to diabetes caused by Alloxan. The normal pattern of histology of pancreas was observed. Keywords: Ethanolic Extract, OECD-423 guidelines

Ethanolic ExtractOECD-423 guidelines
88,086 views
26,444 downloads
DOI:
10.46624/ajphr.2018.v6.i12.002

Contributors:

 G.Sekar
,
 T.Venkatachalam
,
 P.Kalaisevi
,
 and R.Ramprasad
Research PaperID: AJPHR612003

Efficacy of K-Tape in Chronic Mechanical Low Back Pain

Muteb Al Sulaimy, Nezar Al Torairi, Sharick Shamsi, Shabana Khan

ABSTRACTEfficacy of K-Tape in Chronic Mechanical Low Back Pain. Randomized Control Trial. A total of 30 patients were included as per pre define inclusion and exclusion criteria and randomly assigned into two groups, consisting of 15 patients in each group. Group A was given K-Tape along with standardized exercise program. Group B was given standardized exercise program along with moist hot pack for 4 weeks, 3 sessions per week one session per day. The patient’s outcome measures were assessed by visual analog scale, ODI and Goniometry for Lumbar Range of Motion. Measurements were recorded before and after the end of the treatment period.  Results revealed that means and S.D of both group were significant (p=0.000 ) statically but clinically the Group of patients treated with K-Tape along with standardized exercise program managed pain (pre=7.50±1.21,post=0.71±0.37),ODI(pre=41±18.16,post= 8±4.49) and range of motion (flexion pre=31±5.04,post=50±10.12,extension pre=17±2.13,post=29±4.20 Rt side flexion pre=10±2.55,post=22±4.75 and Lt. side flexion pre=10±2.35, post=22±4.63, Rt side  rotation pre= 8±1.27,post=19±2.65) Lt. side rotation pre=8±2.15, post=18±2.46 better than group of patients treated with standardized exercise program along with Moist hot pack in terms of pain (pre=7.81±1.16,post=2.35±1.27), ODI (pre=44±21.32,post=22±10.6) and range of motion (flexion pre=25±5.65,post=37±10.16, extension pre=15±2.55,post=21±5.32, Rt side flexion pre=10±2.35 post=15±2.28, Lt Side flexion pre=11±2.35, post=19±2.36, Rt side rotation pre=9±1.90 post=16.±2.71, Lt Side rotation pre=8±1.63, post=15±3.15. The result of study suggests that both K-Tape and exercises improves the symptoms of chronic low back pain. Better improvement was shown by K-Tape group when compared with exercise group. Based on these results K-Tape and Exercise should be the treatment of choice for chronic mechanical low back pain rather than Exercise with HP. Keywords: K-Tape, Chronic Low Back Pain, Moist hot

K-TapeChronic Low Back PainMoist hot PackExercise.
88,154 views
26,423 downloads
DOI:
10.46624/ajphr.2018.v6.i12.003

Contributors:

 Muteb Al Sulaimy
,
 Nezar Al Torairi
,
 Sharick Shamsi
,
 Shabana Khan
Research PaperID: AJPHR612004

Synthesis and Evaluation of 2-Chloro-3-[3-(6-Methyl-1h-Benzimidazol-2-Yl)-4, 5-Dihydro-1h-Pyrazol-5-Yl] Quinolines as Potent Antimicrobial Agents

B. Shivakumar, Indira. M. Madawali, Shivakumar Hugar and Navanath. V. Kalyane

ABSTRACTA new series of 2-chloro-3-[3-(6-methyl-1H-benzimidazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]quinoline (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with hydrazine hydrate in ethanol and glacial acetic acid. The synthesized compounds were characterized by their IR, 1H NMR and Mass spectral studies. Further, compounds were screened for their antimicrobial activity by cup plate method, using Ciprofloxacin and Fluconazole as a standard drugs. Results of the activities reveal that, compound exhibited moderate to good antibacterial and antifungal activities. Keywords: 6-Methylbenzimidazoles, Chalcones, Pyrazolines, Antimicrobial activity.

6-MethylbenzimidazolesChalconesPyrazolinesAntimicrobial activity.
88,489 views
26,533 downloads
DOI:
10.46624/ajphr.2018.v6.i12.004

Contributors:

 B. Shivakumar
,
 Indira. M. Madawali
,
 Shivakumar Hugar and Navanath. V. Kalyane
Research PaperID: AJPHR612005

Diarrheal Diseases and Awareness at Displaced People Camp

Maria Mubarak, Fatima Fadul Ali, Mohamed Osman Elamin, Alfatih Aburass

ABSTRACTComparing estimates of the current global burden of the diarrheal diseases with previously published estimates, highlights that the incidences of diarrhea have not changed much, although overall diarrhea mortality has declined. For children aged less than five years in developing countries, a median of 3.2 episodes of diarrhea occurred per child-year, which is similar to that reported previously. Estimates of mortality indicate that 4.9 children per 13.6 per 1000 per year died in the developing regions because of diarrhea illness in the first 5 years of life.A cross sectional institution based study was conducted in Alhajaj IDPs camp in Elgeneina locality, Sudan for the Assessment of knowledge, attitudes and practices of displaced people towards diarrheal diseases.  Assessment of Knowledge, attitudes and practice leading diarrheal diseases at the Alhajaj internal displace people camp. The study found that, the knowledge of the community about the common methods of transmission of diarrhoea in the camp are contamination of food, flies, contamination of hands, and contamination of water, in addition 67% of people in camp use tanks as a source of water, 22% of the people use wells, 44% of people are practicing open defecation. The study recommended that activities for raising health awareness of the community and provision of safe water supply and sanitation in the camp are a major priorities. Keywords: Diarrheal diseases, Displaced 

Diarrheal diseasesDisplaced
88,509 views
26,490 downloads
DOI:
10.46624/ajphr.2018.v6.i12.005

Contributors:

 Maria Mubarak
,
 Fatima Fadul Ali
,
 Mohamed Osman Elamin
,
 Alfatih Aburass

Related Issues

Volume 14, Issue 6Current

2026 • 2 articles

Volume 14, Issue 5

2026 • 2 articles

Volume 14, Issue 4

2026 • 1 article

Volume 14, Issue 3

2026 • 3 articles

Whatsapp