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📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

Volume 8, Issue 3 - 2020 (March 2020 Issue 3)

Volume 8 Issue 3 Cover

Issue Details:

Volume 8 Issue 3
Published:Invalid Date

Editorial: March 2020 Issue 3

Welcome to the 2020 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 7 of 7 articles
Research PaperID: AJPHR803001

A Comparative Study to Evaluate the Risk Of Metabolic Syndrome In Premenopausal and Postmenopausal Women

Khushbu Jasotani, Jairam Rawatani

ABSTRACTThe menopausal state is itself noted to be an independent risk factor  for the occurrence of metabolic syndrome. This study was conducted to find the prevalence of metabolic syndrome in postmenopausal women. It was an Observational study. Total 100 females were enrolled, 50 premenopausal(Group I) and 50 menopausal (Group II) were included in the study. There was a statistic significant increase in serum glucose, serum total cholesterol (TC), triglycerides (TG), LDL-cholesterol, VLDL-cholesterol levels, insulin, insulin resistance in post-menopausal women. HDL-cholesterol level and estradiol concentration was significantly lower in post-menopausal women. Menopause leads to changes in blood glucose, serum insulin, lipid profile by reducing HDL, and elevating total cholesterol (TC), triglycerides (TG), LDL-cholesterol and VLDL-cholesterol, thus increasing the risk for cardiovascular disease. These changes are caused by reduced estrogen concentrations which are seen in menopause. Keywords: Menopause, metabolic syndrome, postmenopausal women, cardio vascular disease.

Menopausemetabolic syndromepostmenopausal womencardio vascular disease.
94,369 views
28,474 downloads
DOI:
10.46624/ajphr.2020.v8.i3.001

Contributors:

 Khushbu Jasotani
,
 Jairam Rawatani
Research PaperID: AJPHR803002

A Short Review On Benzimidazole and Their Derivatives

Gayatri D. Patil, Aaditya R. Nikam, Niranjan B. Karanke, Azam Z. Shaikh

ABSTRACTBenzimidazole derivatives are versatile nitrogen containing heterocyclic compound which have long been known as a promising class of biologically active compounds possessing wide variety of a biologically active compound like antiprotozoal, anticoagulant, antifungal, antihistaminic, antiulcer activities. Benzimidazole is outstanding effective compounds and these are a number of reviews available for biochemical and pharmacological studies. This review article covers the most active benzimidazole derivative and discusses the structure and their uses. Keyword: Benzimidazole, Heterocyclic compound, Benzimidazole derivative, Antifungal, Antiprotozoal activity, Antihistaminic

BenzimidazoleHeterocyclic compoundBenzimidazole derivativeAntifungalAntiprotozoal activityAntihistaminic
94,940 views
28,503 downloads
DOI:
10.46624/ajphr.2020.v8.i3.002

Contributors:

 Gayatri D. Patil
,
 Aaditya R. Nikam
,
 Niranjan B. Karanke
,
 Azam Z. Shaikh
Research PaperID: AJPHR803003

Novel Approach for Design and Characterization Of Muco Adhesive Buccal Ganciclovir In Situ Gel

CH.N.V.S.Masthan Rao* R.B.Desireddy, D.Vasavilatha, G.L.S.Mounika, G.Ramya Sadhana, K.L.T.Sowjanya

ABSTRACTThe present study was design to prepare periodontal gel of Ganciclovir for the treatment of inflammation condition. In this study, it was found that as the phospholipid concentration was increased, it resulted in corresponding increase in the entrapment efficiency of reconstituted liposomes. In conclusion, a sustained delivery of Ganciclovir can be achieved by proliposomal drug delivery system. Phospholipids, being the major component of liposomal system, can easily get integrated with the skin lipids and maintain the desired hydration conditions to improve drug permeation. Fusion of lipid vesicles with skin contributed to the permeation enhancement effect. In –vitro studies concluded that enhance skin permeation and retention of Ganciclovir was observed and was due to liposolubulized state of drugs with in proliposomes which helped to produce the depot effect. The prepared proliposomes are in corporated in to gel. The data show that liposomal systems can make the drug molecule more accessible with in skin layers. This conclusion compares favourably with early study showed that drug associated with liposomes bi-layer bounds and better routed into skin. Other studies have shown that liposomal ambiaence may help modify the permeability characteristics of the stratum corneum, and the system keep the drug molecules with in skin layers so that sustain release of drug can be achieved. The results advocate the extension of this work on the preliminary clinical trails and commercialization of proliposomal gel formulation of anti viral drugs for effective topical pharmacotherapy in treatment of virus. Keywords: Ganciclovir, Gellan gum , Mucoadhesive in situ gel

GanciclovirGellan gumMucoadhesive in situ gel
94,892 views
28,438 downloads
DOI:
10.46624/ajphr.2020.v8.i3.003

Contributors:

 CH.N.V.S.Masthan Rao* R.B.Desireddy
,
 D.Vasavilatha
,
 G.L.S.Mounika
,
 G.Ramya Sadhana
,
 K.L.T.Sowjanya
Research PaperID: AJPHR803004

Synthesis of Some Novel 1, 5-Benzothiazepine Derivatives Biological Screening For Anticonvulsant Activity

S.K. Parjane, R. Kunkulol, D. Nandal

ABSTRACTThe presence of recurrent seizures is responsible for epilepsy, further which has been characterized in the era. A seizure can be mention as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex” 1. Epileptic convulsions are expected to have negative consequences on the patient’s psychological and social life such as relationships, education and employment. Uncontrolled seizures are associated with physical and psychosocial morbidity, dependent behavior, poor quality of life and an increased risk of sudden unexpected death. The heterocyclic compound is a potential compound for the development of chemotherapeutic and pharmacotherapeutic agents containing nitrogen and sulphur atoms2. Therefore the present investigation was made in direction to the synthesis of some newer 1, 5-benzothiazepine derivatives and their evaluation for anticonvulsant activity. Physicochemical and elemental analysis of all the 1, 5-benzothiazepine (1B-10B) is confirmed with a preliminary study like melting point, elemental analysis and hyphenated tool namely IR, NMR and Mass spectroscopy. Firstly Primarily, ?,?-unsaturated carbonyl compounds or chalcones were prepared by the well-known Claisen-Schmidt condensation of acetophenones and substituted aldehyde by using alcoholic KOH (10%) at room temperature. By adding diazonium salt in substituted chalcone ,substituted diazonium chalcone was prepared. A yield mixture and 0.01 mole of substituted mercapto anilines was dissolved in 2-methoxyethanol to get final product 1, 5-benzothiazepine derivatives. These molecules were evaluated for possible anticonvulsant activity. Anti-seizure activities of all synthesized compounds 101B to 110B were explored using MES. The synthesized compounds from (101B to 110B) 108B and 109B had shown significant activity against the tonic seizure as compared to the other synthesized compounds. Keywords

15-benzothiazepine derivativesanticonvulsant activity
95,168 views
28,439 downloads
DOI:
10.46624/ajphr.2020.v8.i3.004

Contributors:

 S.K. Parjane
,
 R. Kunkulol
,
 D. Nandal
Research PaperID: AJPHR803005

Development and Validation of RP-HPLC Method For Quantitative Analysis Of Abiraterone In Pure and Pharmaceutical Dosage Form

P. Jitendra Kumar*1 Syed.Rafiya, Tezenile .Magh, T.Venkata Lakshmi, T.Vakya Mani, D.Rama Brahma Reddy

ABSTRACTA simple, Precised, Accurate method was developed for the estimation of Abiraterone by RP-HPLC technique. Chromatographic conditions used are stationary phase  Azilent  C18 (150mm x 4.6 mm, 5m )Mobile phase 0.01%KH2PO4:Acetonitrile  in the ratio of 60:40 and flow rate was maintained at 1.0 ml/min, detection wave length was 235 nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 0.7 for repeatability and 0.2for intermediate precision. LOD and LOQ are 1.629µg/ml and 4.937µg/ml respectively. By using above method assay of marketed formulation was carried out 100.81% was present. Degradation studies of Abiraterone were done, in all conditions purity threshold was more than purity angle and within the acceptable range .Full length method was not performed ; if it is done this method can be used for routine analysis of AbirateroneKeywords: HPLC ,  Abiraterone , Method development , ICH Guidelines  

HPLCAbirateroneMethod developmentICH Guidelines
95,132 views
28,484 downloads
DOI:
10.46624/ajphr.2020.v8.i3.005

Contributors:

 P. Jitendra Kumar*1 Syed.Rafiya
,
 Tezenile .Magh
,
 T.Venkata Lakshmi
,
 T.Vakya Mani
,
 D.Rama Brahma Reddy
Research PaperID: AJPHR803006

Development of New Validated RP-HPLC Method for Estimation of Anastrazole in Bulk and Tablet Dosage Forms

Y.Omini, R.B. Desireddy, A.Anil Kumar, B.Tarun Kumar, CH. Anand Kumar, CH. Srinivas Rao

ABSTRACTA simple, Precised, Accurate method was developed for the estimation of Anastrozole by RP-HPLC technique. Chromatographic conditions used are stationary phase  Azilent  C18 (150mm x 4.6mm, 5mm) Mobile phase 0.01N Kh2Po4:Acetonitrile  in the ratio of 60:40 and flow rate was maintained at 1.0 ml/min, detection wave length was 215 nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. The retention time was found to be 2.248 min. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 0.5 for repeatability and 0.6 for intermediate precision. LOD and LOQ are 0.086µg/ml and 0.261µg/ml respectively. By using above method assay of marketed formulation was carried out 100.11% was present. Degradation studies of Anastrozole were done, in all conditions purity threshold was more than purity angle and within the acceptable range. Full length method was not performed; if it is done this method can be used for routine analysis of Anastrozole. Keywords: HPLC Anastrozole, Method development, ICH Guidelines.

HPLC AnastrozoleMethod developmentICH Guidelines.
95,361 views
28,543 downloads
DOI:
10.46624/ajphr.2020.v8.i3.006

Contributors:

 Y.Omini
,
 R.B. Desireddy
,
 A.Anil Kumar
,
 B.Tarun Kumar
,
 CH. Anand Kumar
,
 CH. Srinivas Rao
Research PaperID: AJPHR803007

Design and Characterization of Colon Specific Matrix tablet of a NSAID by Using Various Polymers.

K.S. Srilatha, Senthilkumar. K, Akhila Lakshmi.N, Krishna Manmhon Sah

ABSTRACTThis short communication reports the pharmacokinetic differences of the glucuronide-conjugated metabolites of magnoflorine and jatrorrhizine between Chinese and African male volunteers. From an earlier report, glucuronidation was determined to be one of the main metabolic pathways and these two compounds were reported to differ significantly between the two races. Pharmacokinetic parameters of half-life,t1/2, time to reach maximum concentration, Tmax, maximum plasma concentration, Cmax, volume of distribution, Vd, area under the concentration-time curve, AUC and clearance, CL were considered. Statistically significant differences were observed in almost all the parameters studied in terms of their glucuronide-conjugated metabolites. The findings indicate the differences in hepatic metabolism of these two compounds between the two races. Keywords: conjugate, glucuronide, metabolite, pharmacokinetics, races.

conjugateglucuronidemetabolitepharmacokineticsraces.
95,390 views
28,562 downloads
DOI:
10.46624/ajphr.2020.v8.i3.007

Contributors:

 K.S. Srilatha
,
 Senthilkumar. K
,
 Akhila Lakshmi.N
,
 Krishna Manmhon Sah

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