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📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

📢 Latest Update: Call for Papers – Special Issue on Pharmacy and Health Research (April 2026 Submission Deadline)

Volume 8, Issue 8 - 2020 (August 2020 Issue 8)

Volume 8 Issue 8 Cover

Issue Details:

Volume 8 Issue 8
Published:Invalid Date

Editorial: August 2020 Issue 8

Welcome to the 2020 issue of American Journal of Pharmacy and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Hemangi J Patel
Editor-in-Chief
American Journal of Pharmacy and Health Research

Articles in This Issue

Showing 7 of 7 articles
Research PaperID: AJPHR808001

QSAR study on the hGPR119 Agonistic Activity of Triazolopyridines

Brij Kishore Sharma, Raghuraj Parihar

ABSTRACTThe hGPR119 agonistic activity of triazolopyridines has been analysed with topological and molecular features with DRAGON software. Analysis of the structural features in conjunction with the biological endpoints in combinatorial protocol in multiple linear regression (CP-MLR) led to the identification of 10 descriptors for modelling the activity. The study clearly suggested the role of path/walk 5-Randic shape index (PW5), mean information vertex degree equality (IVDE), Lovasz-Pelikan index (LP1), atomic properties (mass, van der Waals volume and Sanderson electronegativities) in terms of weighted 2D-autocorrelations (MATS4m, MATS2e, MATS4e and MATS5e) and modified Burden eigenvalues (BELm7 and BEHv8) and total primary sp3 hybridized carbon atoms (nCp) in a molecular structure to optimize the hGPR119 agonistic activities of titled compounds. Applicability domain analysis revealed that the suggested model matches the high quality parameters with good fitting power and the capability of assessing external data and all of the compounds was within the applicability domain of the proposed model and were evaluated correctly. Keywords: QSAR; hGPR119 agonistic activity; Combinatorial protocol in multiple linear regression (CP-MLR) analysis; Dragon descriptors; Triazolopyridine derivatives. 

QSARhGPR119 agonistic activityCombinatorial protocol in multiple linear regression (CP-MLR) analysisDragon descriptorsTriazolopyridine derivatives.
98,085 views
29,428 downloads
DOI:
10.46624/ajphr.2020.v8.i8.001

Contributors:

 Brij Kishore Sharma
,
 Raghuraj Parihar
Research PaperID: AJPHR808002

Formulation Development and Evaluation of Promethazine As A Lozenge

Dandagi Panchaxari Mallappa, Uppinangadi Samritha Bhat

ABSTRACTMotion sickness is a complex syndrome representing symptoms nausea and vomiting. Anti-motion sickness drugs can build up the rate of adaptation without symptoms being evoked. The present study aimed to formulate and evaluate Promethazine hydrochloride as a lozenge to combat flaws in regard to conventional dosage form. The sucking and swallowing process is a simple method for relieving symptoms, the mechanism being development of increased saliva, swallowing and this process equals the Eustachian tubes. Promethazine hydrochloride is a BCS class I, phenothiazine derivative showing antihistamine, sedative and antiemetic effect being a H1 receptor blocking agent, it also acts by blocking the action of acetylcholine and is indefinitely metabolized by the liver. Lozenges were prepared by heating and congealing method with isomalt and sucrose as a base and HPMC E5 in varying concentrations. Preformulation demonstrated compatibility of drugs and excipients coordinated using FT-IR and DSC. Post-compression parameters were studied which included general appearance, thickness, hardness, friability, cooling check, drug content, moisture content and in vitro dissolution as well as microbial test. Factorial design 32 was opted to optimize the formulation. Formulation F3 was considered an engineered medicated confection that met all the requirements showing adequate hardness and disintegration of 10 kg/cm2 and 13.60 seconds respectively with a strong drug release rate of 98.22%. The microbial test showed large inhibition zone which concluded it showed quite good resistance and hence was considered as a promising candidate.Keywords: Motion sickness, Lozenges, Heating, congealing, Zone of inhibition.

Motion sicknessLozengesHeatingcongealingZone of inhibition.
98,077 views
29,361 downloads
DOI:
10.46624/ajphr.2020.v8.i8.002

Contributors:

 Dandagi Panchaxari Mallappa
,
 Uppinangadi Samritha Bhat
Research PaperID: AJPHR808003

Formulation and Evaluation of Topical Gel Using Avocado Extract

Hemant K S Yadav, Shahnaz Usman, Raghad Housam Eddin Zain Alabdin, Halima Shuaibu Ahmed, Hauwa Aminu Usman

ABSTRACTThe aim of the current study was to explore the possibility of formulating a topical gel using avocado extract. The avocado oil was extracted by the locally procured fruit. Different formulations were prepared by changing the concentration of avocado oil and carbopol. The formulations were tested for pH, spreadibility, viscosity, sunscreen activity and antibacterial effect. All the parameters were found to be satisfactory. The formulation exhibited good sunscreen activity and was found effective against selected microorganism. It can be concluded that the formulation can be used in the treatment of different skin infections and for the protection from Sun. Keywords: Avocado, gel, spreadibility and sunscreen.

Avocadogelspreadibility and sunscreen.
97,985 views
29,449 downloads
DOI:
10.46624/ajphr.2020.v8.i8.003

Contributors:

 Hemant K S Yadav
,
 Shahnaz Usman
,
 Raghad Housam Eddin Zain Alabdin
,
 Halima Shuaibu Ahmed
,
 Hauwa Aminu Usman
Research PaperID: AJPHR808004

Su-ul-Qinya and Their Clinical Correlation with Anaemia

Reyaz Ahmad, Md. Razi Ahmad, Md Najibur Rahman, Md Tanwir Alam

ABSTRACTSu-ul-qinya is combination of two words ‘Su’ and ‘qinya. Both are Arabic words where “Su” mean defect and ‘Qinya’ means treasure. By combining both words, it becomes Su-ul-qinya, means defect in the asset of the body respectively since blood is supposed to be the asset of the body; therefore Su-ul-qinya is a disorder in which the blood becomes defected. The terms Faqruddam, qillatu dam and fasaduddam are used as synonymous for Su-ul-qinya. According to Unani literature Su-ul-qinya means defect in the blood. So, keeping the fact in mind want to establish the clinical correlation with anaemia in the light of classical Unani literature as well as modern medicine. Keywords: Su-ul-qinya; Anaemia; Faqruddam; Fasaduddam; Kuriyat-e-hamra.

Su-ul-qinyaAnaemiaFaqruddamFasaduddamKuriyat-e-hamra.
98,065 views
29,534 downloads
DOI:
10.46624/ajphr.2020.v8.i8.004

Contributors:

 Reyaz Ahmad
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanwir Alam
Research PaperID: AJPHR808005

Suddab (Ruta graveolens Linn.) the Blessed Medicinal plant of Unani System of medicine: Literature Review.

Md. Shams Reza, Md. Razi Ahmad, Md Najibur Rahman, Md Tanwir Alam

ABSTRACTPlant of Suddab is commonly cultivated in Indian gardens. The whole plant of Suddab has medicinal value hence used in various diseases and included as an ingredient in a number of formulations. However, its two parts i.e. leaves and seeds are more commonly used. The plant as whole has described to possess Mudir (diuretic), Kasir riyah (carminative), Muhallil and Dafe Alam (analgesic) properties and useful in a number of diverse pathological conditions. In some parts of India, the juice is given to children as a remedy for worms. The use of Suddab since ancient times in different alternative system of medicine like Unani, Ayurveda in single as well as many compound formulations for the treatment of Obesity (Saman-e-Mufrat), Dyslipidemia (Fart-e-Tadassum-Fid-Dum), Atherosclerosis (Salabat-E-Nabz), Anti-helminthic (Deedan-e-medad wa amma) Muhallil and Dafe Alam (Anti-inflammatory & analgesic) etc. Several studies have been carried out for the therapeutic evaluation of its efficacy and safety. So, I want to compile and summarized all the literature at one space.  Keywords: Suddab; Saman-e-Mufrat; Salabt-e-Nabz; Deedan-e-medad wa amma; Muhallil; Dafe Alam.

SuddabSaman-e-MufratSalabt-e-NabzDeedan-e-medad wa ammaMuhallilDafe Alam.
98,363 views
29,551 downloads
DOI:
10.46624/ajphr.2020.v8.i8.005

Contributors:

 Md. Shams Reza
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanwir Alam
Research PaperID: AJPHR808006

Iltihab-E-Tajaweef-E-Anaf Muzmin (Chronic Sinusitis)- A Review

Md. Shams Reza, Md. Razi Ahmad, Md Najibur Rahman, Md Tanveer Alam

ABSTRACTSinusitis is the inflammatory condition involving paranasal sinuses. The paranasal sinuses are air filled spaces in certain bone of skull and they are in direct communication with nasal cavity through their opening called ostia. The clinical manifestation of sinusitis is nasal discharge, headache, blocking of nose, changed nasal resonance, post nasal drip and pain with tenderness in affected sinus. It may be associated with fever occasionally. If the symptoms of sinus inflammation lasting >3 months, then the condition is called chronic sinusitis.1, 2,3,4,5. There is no separate description of chronic sinusitis (Iltehahabe Tajaweef-e-Anaf Muzmin) in Unani literature. Several Unani physicians have described Nazla in lieu of the signs and symptoms of Warm Tajaweef-e- Anaf (sinusitis), with its types haad and muzmin6,7,8. Therefore the search for sinusitis in unani literature seems evasive, but the Unani physicians have rendered the description of Warm (inflammation), tajaweef (Cavities) and Majari (ducts), which can be correlated to present modern concept of sinusitis9,10. The terms Iltehahabe Tajaweef-e-Anaf, Nazla, Zukam and Catarrah are used as synonymous for sinusitis which is classified in haad and Muzmin (acute and chronic). So, keeping the fact in mind want to established the clinical correlation with anaemia in the light of classical Unani literature as well as modern medicine. Keywords: Sinusitis; Iltihab-e-Tajaweef-e-Anaf; Nazla; Zukam; Catarrh; Warm haad & muzmin.

SinusitisIltihab-e-Tajaweef-e-AnafNazlaZukamCatarrhWarm haad & muzmin.
98,671 views
29,503 downloads
DOI:
10.46624/ajphr.2020.v8.i8.006

Contributors:

 Md. Shams Reza
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanveer Alam
Research PaperID: AJPHR808007

Ustukhuddoos (Lavandula Stoechas): the Blessed Herb

Reyaz Ahmad, Md. Razi Ahmad, Md Najibur Rahman, Md Tanwir Alam

ABSTRACTUstukhuddoos has been used as a healing agent since ancient times. Renowned Unani physicians Jalinus and Desquredus discovered varied medicinal properties of this plant origin drug. They recommended using this drug, especially in cerebral disorders. Lavandula stoechas Linn. belongs to Lamiaceae / Labiatae family. This is an evergreen shrub usually grows to 30-100 cm in height. The leaves are 1-4 cm long, greyish and tomentose. The flowers are pink to purple in color appear in late spring and early summer season. In Unani Medicine, it is commonly known as Ustukhuddoos. Unani literatures has mentioned many pharmacological actions of this drug such as Kasir-e-Riyah (Carminative), Mufatteh (Desiccative), Munzij (Attenuent), Muhallil (Resolvent), Mulattif (Demulcent), Muqawwi(Tonic), Munaqqi(Purifier), Jaroob-e-Dimagh (brain scavenger), Daf-e-Sauda (evacuation of black bile), Da-fe-Tashannuj (anti-convulsant), Mufarrah-e-Qalb-Wa-Dimagh (exhilarant of heart and brain), Muqaww-i-Aasab (nervine tonic) etc, and it is used in several ailments such as Zof-e-Dimagh, Nisyan (dementia), Malankholia (malancholia), Waja al qalb (angina pectoris), Suda-e-Muzmin (a chronic headache), Falij (paralysis), Laqwa (facial paralysis) etc. Many scientific studies have been proved that Ustukhuddoos is significantly useful in several neurological disorders such as anxiety, depression, convulsions and cerebral ischemia etc. The present review is an attempt to portray this wonder drug Ustukhuddoos in the light of scientific studies carried out. Keywords: Kasir-e-Riyah; Mufatteh; Munzij; Mulattif; Munaqqi, Muqawwi-e-Asab Jaroob-e-Dimagh. 

Kasir-e-RiyahMufattehMunzijMulattifMunaqqiMuqawwi-e-Asab Jaroob-e-Dimagh.
98,473 views
29,718 downloads
DOI:
10.46624/ajphr.2020.v8.i8.007

Contributors:

 Reyaz Ahmad
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanwir Alam

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