Hydrocortisone Micro Emulsions for Parenteral Drug delivery

Microemulsions are the promising vehicle for administration of active pharmaceutical ingredients. It is an isotropic transparent or translucent thermodynamically stable mixture and used for targeted controlled drug delivery system for the effective delivery of hydrocortisone.  In present study lecithin based o/w microemulsion was developed for parental drug delivery using hydrocortisone as model drug.  Tween 80 and Cremophor–EL were used as co-surfactant and PEG 400 were used as co-solvent; soyabean oil was used as the oil phase.  Formulations prepared with the tween-80 were having both clarity and maximum oil entrapment formulation prepared were characterized for color, appearance pH, viscosity, particle size distribution, Refractive index, effect of centrifugal force, freeze thaw cycle, drug content   in-vitro release profile and TLC.  Prior to stability studies the microemulsion were sterilized by autoclaving. Toxicity studies were performed on Albino mice by injecting them intraperitonialy no mortality was observed, which indicate the safety of these formulations. Therefore the lecithin based microemulsions can be formulated for parenteral drug delivery and obtain sustained or prolonged drug delivery for hydrocortisone having good physical stability.