Design and Evaluation of Mucoadhesive Gel of Glimepiride for Nasal Delivery

Nasal Mucoadhesive gel of Glimepiride was prepared  for  Controlled release.  Carbopol 934p was used as a key ingredient which gives mucoadhesion property to the gel formulations. Different formulations were prepared by varying the concentrations of Carbopol 934p and Hydroxyl Propyl Methyl Cellulose K4M (HPMC K4M). These formulations were evaluated for parameters like pH, Drug content, Viscosity, Mucoadhesive strength, Gel strength, In-vitro drug release, In-vitro permeation and Drug excipient compatibility. In this formulation the release profile depend on the concentration of Carbopol 934p and HPMC K4M. A 32 factorial design was applied to see the effect of  variables Carbopol 934p (X1) and HPMC K4M (X2) on the response percentage drug release  as a dependent variable. In vitro release data were fitted to various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F-statistics were used to select the most appropriate model.  Formulation containing Carbopol 934p(1.0%) and HPMC K4M(1.0%) was found to be  optimum. The studies indicate that the formulation was effective in providing In-vitro release of drug and the mucoadhesive formulation