Study of hepatoprotective activity of Liv' Well liver tonic in CCl4 induced hepatotoxicity in rats

The hepatoprotective activity of Liv’Well liver tonic was investigated using CCl4 (1ml/kg i.p for 7 days from 3rd to 10th day) albino Wistar rat liver. The Liv’Well liver tonic was administered orally at a dose of 200 and 400mg/kg po, for 10 consecutive days. The doses were determined from the acute oral toxicity study in albino mice. The CCl4 was administered to all the groups except group I (normal control). Liv-52 syrup 5ml/kg, p.o was used as a standard hepatoprotective drug. After 24h of the last day treatment, blood was withdrawn by retro orbital puncture and serum SGOT, SGPT, ALP, total bilirubin was determined. Then the animals were sacrificed under ketamine over anesthesia (150mg/kg ip) and the liver was isolated and processed for the histopathological investigation.  The rats treated with Liv’Well + CCl4 significantly reduced the levels of SGOT, SGPT, ALP, total bilirubin when compared to CCl4 hepatotoxic rats. Histopathological examination also reveals the hepatoprotective activity of Liv’Well liver tonic. From the results of the present study, it is concluded that Liv’Well- liver tonic formulated by M/s Suguna Foods Pvt Ltd, Herbal Division, Suguna Lifeherbs Coimbatore, TN, possesses superior hepatoprotective properties that may serve to protect users against diseases associated with hepatic diseases