Self-Emulsifying Drug Delivery System (SEDDS): An Approach To Increase The Solubility Of Lipophilic Drugs

ABSTRACTSolubility of orally administered medication is the significance test for pharmaceutical industry as almost 40% of recently propelled medications have low water solubility which prompts their lower dissolution and bioavailability, bringing about high intra and inter subject changeability and absence of dose proportionality. This can be expanded by various techniques including salt formation, complex formation, solid dispersions. Self-emulsifying drug delivery System (SEDDS) is picking up fame for improving the solvency of lipophilic medications. Self-emulsifying drug delivery systems (SEDDS), which are isotropic blends of oils, surfactants, solvents and co-solvents/co-surfactants which have the novel capacity of forming fine oil-in-water (o/w) micro emulsions upon mild agitation pursued by dilution in aqueous media, i.e., GI fluids. It can be utilized for the formulations so as to improve the oral ingestion of profoundly poorly soluble drugs. Self- emulsifying drug delivery systems are composed of emulsion droplets whose size ranges from 50-500 nm whereas the systems which have droplet size below 50 nm are known as Self-Nano emulsifying drug delivery system (SNEDDS). Keywords: Self- Emulsifying Drug Delivery System, Isotropic Mixtures, Gastrointestinal tract, surfactants, self-emulsification, bioavailability.