Sunitha Reddy M

ABSTRACTNanotechnology is the advancing technology which is based on the study of manipulating the matter on a Nano scale range, and it refers to the constructing and engineering of the functional systems at atomic level. Nanotechnology lead to the development of various types of novel drug delivery systems like liposomes, microparticles, niosomes and proniosomes. Liposomes and niosomes has some demerits like leaking, fusion, aggregation, distribution, transportation and storage. To overcome the demerits of both liposomes and niosomes, proniosomes are developed with enhanced physical stability during storage and transport as they are dry formulation of water soluble carrier encoated with the surfactant and drug encapsulated in the proniosomal vesicles, which helps in prolongation of duration of retention of drug in systemic circulation and by reaching the target tissue shows its action which results in reduced toxicity. This review mainly focusses on demerits of liposomes and niosomes, methods of preparation, characterization and applications of Proniosomes. Keywords: Liposomes, Niosomes, Proniosomes, Stability, Surfactant, Cholesterol, Characterization, Applications.

ABSTRACTSolubility of orally administered medication is the significance test for pharmaceutical industry as almost 40% of recently propelled medications have low water solubility which prompts their lower dissolution and bioavailability, bringing about high intra and inter subject changeability and absence of dose proportionality. This can be expanded by various techniques including salt formation, complex formation, solid dispersions. Self-emulsifying drug delivery System (SEDDS) is picking up fame for improving the solvency of lipophilic medications. Self-emulsifying drug delivery systems (SEDDS), which are isotropic blends of oils, surfactants, solvents and co-solvents/co-surfactants which have the novel capacity of forming fine oil-in-water (o/w) micro emulsions upon mild agitation pursued by dilution in aqueous media, i.e., GI fluids. It can be utilized for the formulations so as to improve the oral ingestion of profoundly poorly soluble drugs. Self- emulsifying drug delivery systems are composed of emulsion droplets whose size ranges from 50-500 nm whereas the systems which have droplet size below 50 nm are known as Self-Nano emulsifying drug delivery system (SNEDDS). Keywords: Self- Emulsifying Drug Delivery System, Isotropic Mixtures, Gastrointestinal tract, surfactants, self-emulsification, bioavailability.