Novel Approach for Design and Characterization Of Muco Adhesive Buccal Ganciclovir In Situ Gel

ABSTRACTThe present study was design to prepare periodontal gel of Ganciclovir for the treatment of inflammation condition. In this study, it was found that as the phospholipid concentration was increased, it resulted in corresponding increase in the entrapment efficiency of reconstituted liposomes. In conclusion, a sustained delivery of Ganciclovir can be achieved by proliposomal drug delivery system. Phospholipids, being the major component of liposomal system, can easily get integrated with the skin lipids and maintain the desired hydration conditions to improve drug permeation. Fusion of lipid vesicles with skin contributed to the permeation enhancement effect. In –vitro studies concluded that enhance skin permeation and retention of Ganciclovir was observed and was due to liposolubulized state of drugs with in proliposomes which helped to produce the depot effect. The prepared proliposomes are in corporated in to gel. The data show that liposomal systems can make the drug molecule more accessible with in skin layers. This conclusion compares favourably with early study showed that drug associated with liposomes bi-layer bounds and better routed into skin. Other studies have shown that liposomal ambiaence may help modify the permeability characteristics of the stratum corneum, and the system keep the drug molecules with in skin layers so that sustain release of drug can be achieved. The results advocate the extension of this work on the preliminary clinical trails and commercialization of proliposomal gel formulation of anti viral drugs for effective topical pharmacotherapy in treatment of virus. Keywords: Ganciclovir, Gellan gum , Mucoadhesive in situ gel