Design and In Vitro Evaluation Of Controlled Release Matrix Tablets Of Prazosin

ABSTRACTTreatment of hypertension with conventional dosage forms is not effective as the drugs do not reach the site of action in appropriate concentration and it is also requiring dosing. Thus, an effective and safe therapy of hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical technologists. Most commonly used method of modulating the drug release is to include it in a matrix system, because of their flexibility, hydrophilic polymer matrix system is widely used in oral controlled drug delivery to obtain a desirable drug release profile, cost effectiveness and broad regulatory acceptance. In present study we have prepared matrix tablet formulations using Prazosin as model drug and Ethyl Cellulose, Two grades of Hydroxy propyl methyl cellulose- HPMC-K4M &HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation F7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compare to other formulations. The short-term stability study proven no change in the formulation upon ageing and it indicates good stability. Keywords: Prazosin, Matrix tablets, Ethyl Cellulose and HPMC-K4M & K100M.